PEEP Titration and Lung Recruitment Potential Assessment by 3D EIT in ARDS Patients

Peking Union Medical College Hospital1 site in 1 country50 target enrollmentJanuary 1, 2024

ConditionsARDS Respiratory Failure

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: ARDS
Sponsor: Peking Union Medical College Hospital
Enrollment: 50
Locations: 1
Primary Endpoint: OD/CL and optimal PEEP monitored by EIT
Status: Recruiting
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

In a population of ARDS patients, we explore the influence of different PEEP levels on regional ventilation distribution, ventilation homogeneity, and the center of ventilation, optimal PEEP and lung recruitment potential as well as the extent of lung collapse and overdistension as detected by 3D-EIT.

Registry

clinicaltrials.gov

Start Date

January 1, 2024

End Date

December 31, 2025

Last Updated

last year

Study Type

Observational

Sex

All

Investigators

Sponsor

Peking Union Medical College Hospital

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•patients on mechanical ventilation.
•Diagnosis of ARDS was based on the Berlin definition
•lung recruitment potential assessment and PEEP titration was proper for the ARDS patients determined by the attending doctor

Exclusion Criteria

•Under 18 years of age.
•Pregnant women;
•Ribcage malformation
•Any contraindication to the use of EIT (e.g. automatic implantable cardioverter defibrillator, and implantable pumps).
•Hemodynamic instability, unable to tolerate high PEEP;
•High-risk individuals with pneumothorax, mediastinal emphysema, etc.

Outcomes

Primary Outcomes

OD/CL and optimal PEEP monitored by EIT

Time Frame: 5-10min

Monitoring the lung collapse and overdistension region by EIT at different PEEP levels. Measure the optimal PEEP level based on collapse and overdistension rate.