Effects of Coffee Consumption on Health Among Adults

Not Applicable

Completed

• Conditions: Health

• Registration Number: NCT03817944
• Lead Sponsor: Zhejiang University

Brief Summary

The purpose of this study is to research the changes of typical thermal processing food intervention on health outcome, metabolites, and gut microbiota, in order to explore the molecular mechanism of interaction between maillard reaction associated hazards and complex food matrix, and provide scientific basis and reference model for combining food nutrition and safety protection.

Detailed Description

This study investigated the association of potato, fried potato, unfried potato, and sweet potato consumption with the incidence of mortality in the China Health and Nutrition Survey (CHNS).We analyzed the CHNS data and the participants (n = 14,116) over 20 years old were followed for up to 22 years. The participants were initially free of cancer, myocardial infarction, apoplexy, and pregnancy. Potato consumption was assessed using validated semi-quantitative food questionnaires (FFQ) in interviews. In each wave of interviews, the participants' situations such as alive, dead, or dying was listed and the death months were recorded. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazard models with adjustment of potential confounders.In the CHNS cohort, total potato, fried potato, unfried potato, and sweet potato consumption were all strongly associated with a reduction in all-cause mortality in both Chinese women and men.

Study Timeline

• Study First Submitted: 2019-01-23
• Study First Submitted QC: 2019-01-23
• Study First Posted: 2019-01-28
• Study Start: 2021-10-18
• Primary Completion: 2021-12-18
• Study Completion: 2021-12-31
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-05
• Last Update Posted: 2025-05-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 156

Inclusion Criteria

• Non-smoking, non-occupational exposed healthy volunteers, 18.5<BMI<30 kg/m^2, were screened. If the evaluation of disease history, blood biochemistry and blood routine was normal, the volunteers were considered healthy.

Exclusion Criteria

• The main exclusion criteria included people with high exposure to cold and fever, recent drug intake (including dietary supplement intake), alcohol intake, vegetarians, pregnancy, high-temperature processed meat and beverages such as coffee and milk tea.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in blood glucose from baseline	8 weeks
Change in blood lipids from baseline	8 weeks

Secondary Outcome Measures

Name	Time	Method
Change in gut microbiota	8 weeks
Urinary biomarkers levels of acrylamide, furans, and furfuryl alcohol	8 weeks; 24 hours	Urinary levels of environmental pollutants (e.g., acrylamide, furans, and furfuryl alcohol), measured using liquid chromatography-mass spectrometry (LC-MS)
Change of metabolites	8 weeks

Trial Locations

Locations (1)

Zhejiang university; 🇨🇳 Hangzhou, China