Influence of Silicone Hydrogel Extended Contact Lens Wear on Corneal Sensitivity
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- difference in corneal sensitivity threshold baseline and after 7 days of extended contact lens wear
Study Overview
Brief Summary
Soft contact lens wear reduces the amount of oxygen reaching the eye, which may have an influence on corneal sensitivity. The aim of this study is to measure corneal sensitivity with means of liquid jet esthesiometry at baseline and after 6 days of continuous, extended contact lens wear.
Detailed Description
Contact lens wear may have an influence on corneal sensitivity, by three mechanisms: hypoxic, mechanical and inflammatory. Extended silicone hydrogel contact lens wear increases the risk of infections. A change in corneal sensitivity may be considered as an indicator for change in corneal physiology. It is there the aim of this study is to measure corneal sensitivity with means of liquid jet esthesiometry at baseline and after 6 days of continuous, extended contact lens wear.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •no contact lens wear three days before first visit
- •corneal radius between 7.4 and 8.0; if corneal radius >8.0, corneal diameter must be at least 12 mm; if corneal radius < 7.4, corneal diameter must be < 12.0
- •OSDI score no higher than 13 points
Exclusion Criteria
- •systemic disease that may have an influence ocular healtjh
- •active ocular disease and no history of ocular surgery
Arms & Interventions
extended contact lens wear
subjects wear silicone hydrogel contact lenses continuously for 7+/- 1 days - corneal sensitivity will be measured and compared at baseline versus after extended contact lens wear
Intervention: silicone hydrogel contact lens (Device)
Outcomes
Primary Outcomes
difference in corneal sensitivity threshold baseline and after 7 days of extended contact lens wear
Time Frame: 7+/-1 days
The difference in corneal sensitivity threshold baseline versus after 7 days of extended contact lens wear will be determined. Corneal sensitivity measurement will take place with the Swiss Liquid Jet Aesthesiometer for Corneal Sensitivity (SLACS) and will be recorded in mbar.
Secondary Outcomes
- correlation between corneal sensitvity threshold and subjective symptoms(7+/-1 days)
Investigators
Daniela Nosch
Clinical Professor
University of Applied Sciences and Arts Northwestern Switzerland