Single-shot Versus Slow Infusion Interscalene Block and Its Impact on Diaphragmatic Function in Patients Undergoing Shoulder Surgery.

Not Applicable

Completed

• Conditions: Brachial Plexus Blockade

• Registration Number: NCT06820853
• Lead Sponsor: Cairo University

Brief Summary

Interscalene brachial plexus block is a commonly chosen anesthetic technique for shoulder and proximal arm surgery yet it carry several risks including phrenic nerve block.

Researchers assumed that slow administration of local anesthetic would reduce incidence of phrenic nerve block

Detailed Description

patients will be randomly allocated into one of 2 groups ( single shot group) and slow administration group . single shot will receive a 10 ml bolus of 0.5% bupivacaine the other group will receive 10 ml 0.5 % bupivacaine over 10 minutes (at a rate of 1ml/minute) using syringe pump An experienced operator who will be blinded to method of administration will conducted diaphragmatic excursion of ipsilateral hemidiaphragm using curved probe at baseline and at 10 minutes interval for 30 minutes Complete phrenic will be defined as 75% or more reduction in DE, while partial failure as 25%-50% reduction in DE

Study Timeline

• Status Verified: 2025-02
• Study First Submitted: 2025-02-06
• Study First Submitted QC: 2025-02-10
• Study First Posted: 2025-02-11
• Study Start: 2025-02-16
• Primary Completion: 2025-05-19
• Study Completion: 2025-05-19
• Last Update Submitted: 2025-05-19
• Last Update Posted: 2025-05-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• ASA I or II undergoing shoulder surgery under GA

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Complete phrenic nerve block defined as > 75% reduction in diaphragmatic excursion	baseline and 30 minutes after the block	defined as \> 75% reduction in diaphragmatic excursion

Secondary Outcome Measures

Name	Time	Method
partial phrenic block	baseline and 30 minutes after the block	25-50% reduction in DE

Trial Locations

Locations (1)

Cairo University; 🇪🇬 Cairo, Giza Governorate, Egypt