Stress Echocardiography in Patients Recovery From Mild COVID-19 Illness

• Conditions: Echocardiography, Stress; COVID-19; Hypertension, Pulmonary

• Registration Number: NCT04498299
• Lead Sponsor: Miguel Ayala León

Brief Summary

With the appearance of the new SARS-COV2 virus, additional challenges are being imposed on the medical community after the resolution of acute COVID-19 illness, resulting in specific pathophysiologic mechanisms that while acutely damage the lung parenchyma might chronically impact the cardiopulmonary system.

This study aims to investigate changes after mild COVID-19 illness in echocardiographic indices at rest and stress.

Detailed Description

Not available

Study Timeline

• Status Verified: 2020-07
• Study First Submitted: 2020-07-31
• Study First Submitted QC: 2020-07-31
• Last Update Submitted: 2020-07-31
• Study First Posted: 2020-08-04
• Last Update Posted: 2020-08-04
• Study Start: 2020-09-01
• Primary Completion: 2020-10-01
• Study Completion: 2020-11-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Having suffered mild COVID-19 illness
• PCR test negative after COVID-19 illness
• Men or women
• Age ≥18 years and < 45.
• No history of other cardiovascular or lung disease.
• No cardiovascular risk factors, that is, arterial systemic hypertension, smoking, diabetes, dyslipidemia
• No ongoing or previous cardio or vasoactive treatment
• Able to use the semi-supine exercise bicycle
• Able to give informed consent

Exclusion Criteria

• Poor acoustic window.
• Tricuspid regurgitation more than mild
• Professional sports activity
• Pregnancy
• Obesity (body mass index [BMI], ≥30 kg/m2).
• Inability to provide consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
• LA volume index	3 minutes	Left atrium volume index
• A tricuspid (A)	3 minutes	A triuspid (A)
• LV telediastolic diameter	3 minutes	Left ventricle telediastolic diameter
• LV posterior wall	3 minutes	Left ventricle posterior wall
• RA area	3 minutes	Right atrium area
• Proximal RV outflow tract dimension at the proximal subvalvular level	3 minutes	Proximal right ventricle outflow tract dimension at the proximal subvalvular level
• Inferior cava vein PW Doppler	3 minutes	Inferior cava vein PW Doppler
• RV mid cavity dimension;	3 minutes	Right ventricle cavity dimensión
• Distal, RV outflow tract dimension at the distal or pulmonic valve level	3 minutes	Distal, right ventricle outflow tract dimension at the distal or pulmonic valve level
• E wave mitral	3 minutes	E wave mitral
• LV telesystolic diameter	3 minutes	Left ventricle telesystolic diameter
• RV basal dimensión	3 minutes	Right ventricle basal dimensión
• RV longitudinal dimension	3 minutes	Right ventricle longitudinal dimension
• E-wave at mitral annulus	3 minutes	E-wave at mitral annulus
• E-wave at mitral annulus / A-wave at the mitral annulus	3 minutes	E-wave at mitral annulus / A-wave at the mitral annulus
• TAPSE	3 minutes	• Tricuspid annular plane systolic excursion
• RV free Wall strain	3 minutes	Right ventricle free Wall strain
• A wave mitral	3 minutes	A wave mitral
• E wave /A wave mitral	3 minutes	E wave /A wave mitral
• E tricuspid (E)	3 minutes	E tricuspid (E)
• E/A	3 minutes	E/A
• Stroke volume	3 minutes	Stroke volume
• E wave/ E-wave at the mitral annulus	3 minutes	E wave/ E-wave at the mitral annulus
• E-wave at the tricuspid annulus	3 minutes	E-wave at the tricuspid annulus
• Cardiac output	3 minutes	Cardiac output
• Systolic pulmonary artery pressure	3 minutes	Systolic pulmonary artery pressure
• Mean pulmonary artery pressure	3 minutes	Mean pulmonary artery pressure

Trial Locations

Locations (1)

Hospital Beneficencia Española de Puebla; 🇲🇽 Puebla, Mexico