Efficacy Of Oral Dexamethasone Versus Parenteral Dexamethasone In The Management Of Mild To Moderate Croup
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Settlement of symptoms of Croup
研究概览
简要总结
Croup (laryngotracheobronchitis) is a viral infection of the upper airway that causes throat swelling, leading to a barking cough, stridor, and hoarseness. It mainly affects children aged 6 months to 12 years, peaking at around 2 years. Most cases are mild and self-limiting. Emergency treatments include cool mist, nebulized epinephrine, and steroids. Steroid therapy, particularly dexamethasone (oral or intramuscular), is commonly used, with recent studies suggesting intramuscular dexamethasone may be more effective. However, most research has focused on hospitalized patients, and there is a lack of local data for mild cases. This study aims to address that gap and improve patient counseling and future research
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 2 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient age 2 to 12 years
- •Both genders
- •Diagnosed with croup as operational definitions
排除标准
- •Patients with chronic pulmonary disease like tuberculosis,
- •Allergy or contraindication of corticosteroid (history of tuberous sclerosis, history of varicella infection during the past three weeks), to corticosteroids,
- •history of corticosteroid administration during the last four weeks,
- •foreign body
- •patients with immunodeficiency disorder
研究组 & 干预措施
Group A (oral dexamethasone )
Patients in group A will receive oral dexamethasone which will be administered at 0.6mg/kg as single dose
干预措施: oral dexamethasone (Drug)
Group B (intramuscular dexamethasone )
Patients in group B will receive intramuscular dexamethasone which will be administered in 0.6mg/kg strength as intra-gluteal injection as single dose
干预措施: intramuscular dexamethasone (Drug)
结局指标
主要结局
Settlement of symptoms of Croup
时间窗: within 24 hours
complete or partial settlement of symptoms i.e barking cough, inspiratory stridor, difficulty in breathing and hoarseness of voice.
次要结局
未报告次要终点
研究者
Arooj Khan
Post Graduate Resident, Department of Child Health
Khyber Teaching Hospital