MedPath

Prospective Data Collection of Elderly Patients With DLBCL Receiving at the Time of Diagnosis VGM

Conditions
Lymphoma, Large B-Cell, Diffuse
Registration Number
NCT02364050
Lead Sponsor
Fondazione Italiana Linfomi - ETS
Brief Summary

Prospective data collection of a consecutive series of elderly patients with large B-cell lymphoma newly diagnosed, receiving before the start of treatment Multidimensional Geriatric Assessment (VGM) through the use of Activity of Daily Living (ADL), Instrumental Activity of Daily Living (IADL) and Cumulative Illness Rating Scale for Geriatrics (CIRS-G).

Detailed Description

Prospective data collection of a consecutive series of elderly patients with large B-cell lymphoma newly diagnosed, receiving before the start of treatment Multidimensional Geriatric Assessment (VGM) through the use of Activity of Daily Living (ADL), Instrumental Activity of Daily Living (IADL) and Cumulative Illness Rating Scale for Geriatrics (CIRS-G) to be defined in 3 categories:

* elderly FIT (ADL 6; IADL 8; 0 score= 3-4, \< 5 score=2)

* elderly UNIFIT (ADL 5; IADL 6-7; 0 score= 3-4, 5-8 score=2; ≥ 80 fit)

* elderly FRAIL (ADL ≤ 4; IADL ≤ 5; 1 score= 3-4, \> 8 score=2; ≥ 80 unfit)

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
1300
Inclusion Criteria
  • Patient with Large B-cell Lymphoma
  • Age ≥ 65 years
  • informed Consent
Exclusion Criteria
  • Violation of inclusion criteria
  • Abscence of data considered essential for the study
  • Withdrawal of Consent

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
OS5 years

Overall survival

Secondary Outcome Measures
NameTimeMethod
PFS5 years

Progression free survival

Early mortality rate5 years
% of patients who performed pre-phase therapy5 years

Come to the prefect Therapy is a steroid-based therapy (administered at dosage of at least 25 mg / day) and / or vincristine, which precedes the beginning of the program of chemoimmunotherapy.

Response to initial therapy5 years
FFS5 years

Failure Free Survival

Trial Locations

Locations (55)

Azienda Ospedaliera Caravaggio

🇮🇹

Treviglio, Bergamo, Italy

A.O.Cardinale Panico Ematologia e centro trapianti

🇮🇹

Tricase, LE, Italy

IRCCS Humanitas

🇮🇹

Rozzano, Milano, Italy

CRO-Centro di Riferimento Oncologico

🇮🇹

Aviano, Pordenone, Italy

CROB

🇮🇹

Rionero in Vulture, Potenza, Italy

Polo Pontino

🇮🇹

Latina, Roma, Italy

ASL TO-4

🇮🇹

Ivrea, Torino, Italy

Ospedale S. Giacomo di Castelfranco Veneto

🇮🇹

Castelfranco Veneto, Treviso, Italy

AO SS.Antonio e Biagio

🇮🇹

Alessandria, Italy

AOU Ospedali Riuniti

🇮🇹

Ancona, Italy

Scroll for more (45 remaining)
Azienda Ospedaliera Caravaggio
🇮🇹Treviglio, Bergamo, Italy

MedPath

Empowering clinical research with data-driven insights and AI-powered tools.

© 2025 MedPath, Inc. All rights reserved.