Assessment of Retinal Microvascular Changes by OCT Angiography and Their Correlation With Visual Acuity and Glycemic Control Across Different Stages of Diabetic Retinopathy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Retinal Microvascular Changes Measured by OCT Angiography
研究概览
简要总结
This observational cross-sectional study aims to assess retinal microvascular changes using optical coherence tomography angiography (OCTA) in patients with diabetic retinopathy. The study will evaluate retinal vessel density and foveal avascular zone parameters and investigate their correlation with best-corrected visual acuity and glycemic control (HbA1c) across different stages of diabetic retinopathy. The findings may improve understanding of retinal microvascular alterations and their clinical significance.
详细描述
Diabetic retinopathy is one of the leading causes of visual impairment worldwide. Optical coherence tomography angiography (OCTA) is a non-invasive imaging technique that provides detailed visualization of the retinal microvasculature without the need for dye injection.
This observational cross-sectional study will be conducted at the Department of Ophthalmology, Faculty of Medicine, Sohag University. Adult patients diagnosed with different stages of diabetic retinopathy will undergo comprehensive ophthalmic examination, including best-corrected visual acuity assessment, fundus examination, OCT, and OCT angiography.
Retinal microvascular parameters, including vessel density in the superficial and deep capillary plexuses and the foveal avascular zone (FAZ), will be measured. HbA1c values will be recorded to assess glycemic control.
The primary objective is to evaluate retinal microvascular changes detected by OCTA and determine their correlation with visual acuity and glycemic control across different stages of diabetic retinopathy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Inclusion Criteria:
- •Adults aged 18 to 80 years.
- •Patients diagnosed with diabetic retinopathy.
- •Ability to undergo complete ophthalmic examination including OCT and OCT angiography.
- •Availability of HbA1c measurement within the study period.
- •Ability and willingness to provide written informed consent.
排除标准
- •Previous vitreoretinal surgery.
- •Significant media opacity affecting image quality (e.g., dense cataract or vitreous hemorrhage).
- •Other retinal vascular diseases (e.g., retinal vein occlusion).
- •Glaucoma or optic nerve diseases affecting visual function.
- •High myopia (>6 diopters).
- •Poor-quality OCTA images due to motion artifacts or poor fixation.
- •Refusal or inability to provide informed consent.
- •Exclusion Criteria:
结局指标
主要结局
Retinal Microvascular Changes Measured by OCT Angiography
时间窗: Baseline
Assessment of retinal microvascular parameters including vessel density in the superficial and deep capillary plexuses and the foveal avascular zone (FAZ) using OCT angiography, and their correlation with best-corrected visual acuity and HbA1c.
次要结局
- Correlation Between OCTA Parameters, Visual Acuity, and Glycemic Control(Baseline)
研究者
Omnia Mohamed Abdelziz
Altahrir street sohag
Sohag University