A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men
- Conditions
- HypogonadismCardiovascular Diseases
- Interventions
- Drug: AndroGel®Drug: Placebo
- Registration Number
- NCT03518034
- Lead Sponsor
- AbbVie
- Brief Summary
This is a double-blinded and placebo-controlled study of topical testosterone replacement therapy (TRT) in symptomatic hypogonadal men with pre-existing cardiovascular disease (CVD) or increased risk for CVD.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 5246
- Men between 45 and 80 years age
- Participants with low serum testosterone concentrations (< 300 ng/dL) who exhibit at least one sign or symptom of hypogonadism and have evidence of cardiovascular (CV) disease or are at an increased risk for CV disease.
- Participants with congenital or acquired hypogonadism for whom long-term therapy with placebo would not be medically appropriate
- Participants with prostate specific antigen (PSA) > 3.0 ng/mL (or 1.5 if on 5-alpha reductase inhibitors)
- Participants who have been treated with testosterone in the past 6 months and for whom testosterone therapy is contraindicated
- Confirmed testosterone < 100 ng/dL
- Body Mass Index (BMI) > 50
- Hemoglobin A1c (HbA1C) > 11%
- Hematocrit (Hct) > 50%
- Estimated Glomerular Filtration Rate (eGFR) < 30 ml/min
- History of deep vein thrombosis or pulmonary embolism or prostate cancer or heart failure (Class III and IV).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description AndroGel 1.62% AndroGel® Participants receive topical testosterone starting with a 40.5 mg dose (2 pump actuations) of the study drug once daily (OD). Participants may receive a dose in the range of 20.25 mg (1 actuation) to 101.25 mg (5 actuations) in 20.25 mg increments during the course of the study if titrations are necessary. Placebo Placebo Participants receive matching placebo OD.
- Primary Outcome Measures
Name Time Method Time From Randomization to the First Component Event of Major Adverse Cardiac Event (MACE): Number and Percentage of Participants With an Event Randomization to event or last known date if no event (up to approximately 52 months) MACE is a composite endpoint including non-fatal myocardial infraction (MI), non-fatal stroke and cardiovascular (CV) death as adjudicated by Clinical Events Committee (CEC).
Time From Randomization to the First Component Event of MACE Randomization to event or last known date if no event (up to approximately 52 months) MACE is a composite endpoint including non-fatal MI, non-fatal stroke and CV death as adjudicated by CEC.
- Secondary Outcome Measures
Name Time Method Incidence of High-Grade Prostate Cancer Randomization to event or last known date if no event (up to approximately 52 months). Presented as the number and percentage of participants with any high grade prostate cancer, defined as Gleason grade of 4 + 3 or higher, as adjudicated by Prostate Safety Events Committee (PAC). This grade is based on how abnormal prostate cells appear. Grade 1: cells look almost like normal prostate cells; Grade 5; cells look very different from normal prostate cells. Since most prostate cancers contain cells of different grades, the 2 most common grades are used. Gleason score is determined by adding the 2 most common grades. Higher numbers indicate a faster growing cancer that is more likely to spread. Currently the lowest score assigned to a tumor is grade 3. Grades below 3 show normal to near normal cells. Most cancers have a Gleason score (the sum of the 2 most common grades) of 6 (Gleason scores of 3+3) or 7 (Gleason scores of 3+4 or 4+3).
Time From Randomization to the First Component Event of CV Safety Endpoint: Number and Percentage of Participants With an Event Randomization to event or last known date if no event (up to approximately 52 months). The CV safety endpoint is a composite endpoint including non-fatal MI, non-fatal stroke, CV death, and coronary revascularization procedures/cardiac percutaneous coronary intervention (PCI), or coronary artery bypass graft (CABG) as adjudicated by CEC.
Time From Randomization to the First Component Event of CV Safety Endpoint Randomization to event or last known date if no event (up to approximately 52 months). The CV safety endpoint is a composite endpoint including non-fatal MI, non-fatal stroke, CV death, and coronary revascularization procedures/cardiac PCI, or CABG as adjudicated by CEC.
Trial Locations
- Locations (384)
Founders Research Corp /ID# 170610
🇺🇸Philadelphia, Pennsylvania, United States
Alliance for Multispecialty Research- Norman /ID# 170581
🇺🇸Norman, Oklahoma, United States
Maryland Cardiovascular Specialists /ID# 168057
🇺🇸Baltimore, Maryland, United States
Johns Hopkins University /ID# 203006
🇺🇸Baltimore, Maryland, United States
Centennial Medical Group /ID# 170568
🇺🇸Elkridge, Maryland, United States
Atlanta Vascular Research Foundation - Atlanta Clinical Research Centers /ID# 170894
🇺🇸Atlanta, Georgia, United States
American Health Network of IN, LLC (Avon) /ID# 170359
🇺🇸Avon, Indiana, United States
Synexus Clinical Research US, Inc /ID# 209956
🇺🇸Chicago, Illinois, United States
Michael E. DeBakey VA Medical Center /ID# 167598
🇺🇸Houston, Texas, United States
The Endocrine Center /ID# 170653
🇺🇸Houston, Texas, United States
VA Puget Sound Health Care System /ID# 170555
🇺🇸Seattle, Washington, United States
Panax Clinical Research /ID# 170525
🇺🇸Miami, Florida, United States
Pharmax Research Clinic /ID# 170403
🇺🇸Miami, Florida, United States
APF Research, LLC. /ID# 170412
🇺🇸Miami, Florida, United States
Advanced Pharma CR, LLC /ID# 167840
🇺🇸Miami, Florida, United States
Future Care Solution LLc /ID# 170361
🇺🇸Miami, Florida, United States
Care Research center Inc. /ID# 167924
🇺🇸Miami, Florida, United States
Floridian Research Institute LLC /ID# 167882
🇺🇸Miami, Florida, United States
Clinical Research of So Nevada /ID# 167594
🇺🇸Las Vegas, Nevada, United States
Sheldon Freedman MD, ltd /ID# 170434
🇺🇸Las Vegas, Nevada, United States
Cincinnati Veterans Affairs Medical Center /ID# 170385
🇺🇸Cincinnati, Ohio, United States
Ritchken & First MD's /ID# 201341
🇺🇸San Diego, California, United States
Herman Clinical Research, LLC /ID# 170474
🇺🇸Suwanee, Georgia, United States
North Georgia Clinical Research /ID# 170467
🇺🇸Woodstock, Georgia, United States
Elite Clinical Studies, LLC /ID# 168058
🇺🇸Phoenix, Arizona, United States
Tatum Highlands Medical Assoc /ID# 208277
🇺🇸Phoenix, Arizona, United States
Verde Valley Medical Center /ID# 202955
🇺🇸Tucson, Arizona, United States
Synexus Clinical Research US, Inc. /ID# 210230
🇺🇸Anderson, South Carolina, United States
Medicor Cardiology /ID# 170436
🇺🇸Bridgewater, New Jersey, United States
Advanced Biomedical Research of America /ID# 202202
🇺🇸Las Vegas, Nevada, United States
Synexus Clinical Research US, Inc. /ID# 210232
🇺🇸Henderson, Nevada, United States
AB Clinical Trials /ID# 170612
🇺🇸Las Vegas, Nevada, United States
Palm Research Center, Inc. /ID# 168224
🇺🇸Las Vegas, Nevada, United States
IMA Clinical research- Warren /ID# 170452
🇺🇸Warren, New Jersey, United States
New Phase Research & Development /ID# 170526
🇺🇸Knoxville, Tennessee, United States
Collierville Medical Specialists /ID# 170328
🇺🇸Collierville, Tennessee, United States
DeGarmo Institute of Medical Research /ID# 170528
🇺🇸Greer, South Carolina, United States
Holston Medical Group (Seasons of Bristol) /ID# 170565
🇺🇸Bristol, Tennessee, United States
Holston Medical Group Clinical /ID# 168165
🇺🇸Kingsport, Tennessee, United States
Trinity Clinical Research, LLC /ID# 170369
🇺🇸Tullahoma, Tennessee, United States
Phoenix VA Health Care System /ID# 167968
🇺🇸Phoenix, Arizona, United States
Central Phoenix Medical Clinic /ID# 170333
🇺🇸Phoenix, Arizona, United States
Lynn Health Science Institute East /ID# 170497
🇺🇸Oklahoma City, Oklahoma, United States
Victorium Clinical Research /ID# 168112
🇺🇸San Antonio, Texas, United States
Northeast Clinical Research of San Antonio, LLC /ID# 202951
🇺🇸San Antonio, Texas, United States
Discovery Clinical Trials-San Antonio /ID# 200845
🇺🇸San Antonio, Texas, United States
ALM VA Hospital /ID# 167973
🇺🇸San Antonio, Texas, United States
Loretto Hospital.Affnity Clinical Research Institute /ID# 207262
🇺🇸Chicago, Illinois, United States
Edward Hines Jr. VA Hospital /ID# 167944
🇺🇸Hines, Illinois, United States
Solaris Clinical Research /ID# 202936
🇺🇸Meridian, Idaho, United States
Institute of Arthritis Research /ID# 170495
🇺🇸Idaho Falls, Idaho, United States
Biofortis, Inc. /ID# 167856
🇺🇸Addison, Illinois, United States
Dupage Medical Group /ID# 219039
🇺🇸Evergreen Park, Illinois, United States
Chicago Clinical Research Institute, Inc /ID# 203190
🇺🇸Chicago, Illinois, United States
Affinity Health /ID# 202552
🇺🇸Oak Brook, Illinois, United States
American Health Network of IN, LLC (Avon) /ID# 170483
🇺🇸Franklin, Indiana, United States
Pharmakon Inc /ID# 206149
🇺🇸Evergreen Park, Illinois, United States
Urology of Indiana - Naab Road /ID# 203469
🇺🇸Indianapolis, Indiana, United States
Midwest Endocrinology /ID# 202992
🇺🇸Crystal Lake, Illinois, United States
Koch Family Medicine SC /ID# 202205
🇺🇸Morton, Illinois, United States
Investigative Clinical Research of Indiana, LLC /ID# 170473
🇺🇸Elwood, Indiana, United States
Richard L. Roudebush VA Medical Center /ID# 203020
🇺🇸Indianapolis, Indiana, United States
Investigators Research Group, LLC /ID# 170557
🇺🇸Brownsburg, Indiana, United States
West Broadway Clinic /ID# 202204
🇺🇸Council Bluffs, Iowa, United States
Heartland Research Associates, LLC /ID# 203031
🇺🇸El Dorado, Kansas, United States
Iowa Diabetes and Endocrinology Research Center /ID# 170462
🇺🇸West Des Moines, Iowa, United States
Alliance for Multispecialty Research (AMR) - Wichita West /ID# 170415
🇺🇸Wichita, Kansas, United States
Alexandria Cardiology Clinic /ID# 170463
🇺🇸Alexandria, Louisiana, United States
Med Research One /ID# 167923
🇺🇸Florissant, Missouri, United States
Centex Studies, Inc /ID# 170416
🇺🇸Lake Charles, Louisiana, United States
Tandem Clinical Research, LLC /ID# 206203
🇺🇸Marrero, Louisiana, United States
Barnum Internal Medicine /ID# 170343
🇺🇸Natchitoches, Louisiana, United States
Oakland Medical Research /ID# 170389
🇺🇸Troy, Michigan, United States
Olive Branch Family Med Ctr /ID# 170409
🇺🇸Olive Branch, Mississippi, United States
Arcturus Healthcare, PLC, Troy Internal Medicine Research Division /ID# 170431
🇺🇸Troy, Michigan, United States
David M. Headley, MD, P.A. /ID# 205428
🇺🇸Port Gibson, Mississippi, United States
NECCR PrimaCare Research, LLC /ID# 170326
🇺🇸Fall River, Massachusetts, United States
Allied Clinical Research /ID# 210859
🇺🇸Reno, Nevada, United States
Montana Medical Research /ID# 170579
🇺🇸Missoula, Montana, United States
Cooper Health System /ID# 170417
🇺🇸Camden, New Jersey, United States
Union Square Medical Associates,PC /ID# 170346
🇺🇸Elizabeth, New Jersey, United States
Internal Medicine Associates /ID# 170538
🇺🇸Bridgeton, New Jersey, United States
Synexus Clinical Research US, Inc. /ID# 209957
🇺🇸Saint Louis, Missouri, United States
Skyline Medical Center /ID# 168234
🇺🇸Elkhorn, Nebraska, United States
Albany Stratton VA Medical Center /ID# 167862
🇺🇸Albany, New York, United States
Mercy Clinic Endocrinology, LLC /ID# 170367
🇺🇸Springfield, Missouri, United States
NY Total Medical Care, PC /ID# 170423
🇺🇸Brooklyn, New York, United States
OnSite Clinical Solutions, LLC - Hickory /ID# 170449
🇺🇸Charlotte, North Carolina, United States
Mid Hudson Medical Research, PLLC /ID# 170511
🇺🇸New Windsor, New York, United States
Premier Medical Group of the Hudson Valley PC /ID# 170456
🇺🇸Poughkeepsie, New York, United States
Manhattan Medical Research /ID# 167956
🇺🇸New York, New York, United States
OnSite Clinical Solutions, LLC /ID# 170634
🇺🇸Charlotte, North Carolina, United States
Rapha Institute for Clinical Research /ID# 170362
🇺🇸Fayetteville, North Carolina, United States
Northstate Clinical Research /ID# 170414
🇺🇸Lenoir, North Carolina, United States
Bland Clinic, PA /ID# 204943
🇺🇸Greensboro, North Carolina, United States
Endocrinology Associates, Inc. /ID# 168113
🇺🇸Columbus, Ohio, United States
Carteret Medical Group LLC /ID# 170771
🇺🇸Morehead City, North Carolina, United States
Diabetes and Endocrinology Associates of Stark County Inc /ID# 170356
🇺🇸Canton, Ohio, United States
Synexus Clinical Research US, Inc. /ID# 210234
🇺🇸Columbus, Ohio, United States
Diabetes & Endocrinology Consultants /ID# 201589
🇺🇸Morehead City, North Carolina, United States
Feasterville Family Health Care Center /ID# 168235
🇺🇸Feasterville, Pennsylvania, United States
Lynn Health Science Institute (LHSI) /ID# 202973
🇺🇸Oklahoma City, Oklahoma, United States
Family Medical Associates of Raleigh /ID# 203979
🇺🇸Raleigh, North Carolina, United States
PriMed Clinical Research /ID# 170310
🇺🇸Dayton, Ohio, United States
Dayton VA Medical Center /ID# 168251
🇺🇸Dayton, Ohio, United States
Advanced Medical Research /ID# 170488
🇺🇸Maumee, Ohio, United States
Velocity clinical research /ID# 170513
🇺🇸Cleveland, Ohio, United States
IPS Research Company /ID# 168117
🇺🇸Oklahoma City, Oklahoma, United States
Synexus Clinical Research, Inc /ID# 202976
🇺🇸Akron, Ohio, United States
Heritage Valley Medical Group /ID# 170387
🇺🇸Beaver, Pennsylvania, United States
Velocity Clinical Research /ID# 170460
🇺🇸Blue Ash, Ohio, United States
Goshen Medical Center - Vineland /ID# 170342
🇺🇸Whiteville, North Carolina, United States
Gabrail Cancer Center Research /ID# 170533
🇺🇸Canton, Ohio, United States
The Ohio State University Wexner Medical Center - Department of Urology /ID# 170551
🇺🇸Columbus, Ohio, United States
Synexus Research Cincinnati /ID# 209958
🇺🇸Cincinnati, Ohio, United States
Frontier Clinical Research /ID# 167842
🇺🇸Smithfield, Pennsylvania, United States
Ocean State Clin Rese Part,LLC /ID# 170547
🇺🇸Lincoln, Rhode Island, United States
Frontier Clinical Research, LLC - Scottdale /ID# 167864
🇺🇸Scottdale, Pennsylvania, United States
Pittsburgh VA Medical Center-University Drive /ID# 205837
🇺🇸Pittsburgh, Pennsylvania, United States
Main Street Physician's Care - Waterway /ID# 210441
🇺🇸Little River, South Carolina, United States
Self Medical Group - Advanced /ID# 170336
🇺🇸Hodges, South Carolina, United States
Synexus Clinical Research US, Inc. /ID# 210237
🇺🇸Greer, South Carolina, United States
PMG Research of Charleston /ID# 170572
🇺🇸Mount Pleasant, South Carolina, United States
Palmetto Institute of Clinical Research, Inc. /ID# 170395
🇺🇸Pelzer, South Carolina, United States
University Diabetes & Endocrine Consultants /ID# 170392
🇺🇸Chattanooga, Tennessee, United States
Palmetto Clinical Research /ID# 170524
🇺🇸Summerville, South Carolina, United States
Monument Health Clinical Research /ID# 170576
🇺🇸Rapid City, South Dakota, United States
PMG Research of Knoxville /ID# 170393
🇺🇸Jefferson City, Tennessee, United States
Baptist Memorial Medical Group Endocrine Clinic /ID# 168061
🇺🇸Memphis, Tennessee, United States
PMG Research of Knoxville /ID# 170451
🇺🇸Knoxville, Tennessee, United States
Clinical Neuroscience Solutions - Memphis /ID# 170559
🇺🇸Memphis, Tennessee, United States
PMG Research of Knoxville /ID# 170514
🇺🇸Knoxville, Tennessee, United States
Discovery MM Services, Inc - Katy /ID# 202958
🇺🇸Houston, Texas, United States
Centex Studies, Inc. - Houston /ID# 170537
🇺🇸Houston, Texas, United States
Village Medical-MCA /ID# 170443
🇺🇸Houston, Texas, United States
Covenant Clinical Research, PA /ID# 170564
🇺🇸San Antonio, Texas, United States
Arlington Family Research Center, Inc /ID# 170366
🇺🇸Arlington, Texas, United States
Veterans Affairs North Texas Health Care System /ID# 170325
🇺🇸Dallas, Texas, United States
Methodist Urology Associates /ID# 170575
🇺🇸Houston, Texas, United States
Pioneer Research Solutions - Houston /ID# 170379
🇺🇸Houston, Texas, United States
Village Health Partners - Legacy Medical Village /ID# 170659
🇺🇸Frisco, Texas, United States
DCT-AACT, LLC dba Discovery Clinical Trials /ID# 170394
🇺🇸Pflugerville, Texas, United States
DeLeon Research /ID# 210861
🇺🇸Plano, Texas, United States
Texas Cardio Association of Ho /ID# 170494
🇺🇸Kingwood, Texas, United States
Urology Clinics of North Texas /ID# 203033
🇺🇸Dallas, Texas, United States
Discovery MM Services, Inc - Houston - Broadway St /ID# 170558
🇺🇸Houston, Texas, United States
Endocrine and Psychiatry Cente /ID# 170520
🇺🇸Houston, Texas, United States
South Texas Cardiovascular Consultants /ID# 203088
🇺🇸San Antonio, Texas, United States
Texas Diabetes and Endocrinology - South Austin /ID# 170517
🇺🇸Round Rock, Texas, United States
North TX Endocrine Center /ID# 170552
🇺🇸Dallas, Texas, United States
San Gabriel Clinical Research /ID# 167929
🇺🇸Georgetown, Texas, United States
FMC Science /ID# 170407
🇺🇸Lampasas, Texas, United States
Discovery MM Services, Inc. /ID# 170562
🇺🇸Missouri City, Texas, United States
Research Across America /ID# 168229
🇺🇸Plano, Texas, United States
Crossroads Clinical Research, /ID# 170372
🇺🇸Victoria, Texas, United States
Northwest Houston Clinical Research PLLC /ID# 168223
🇺🇸Tomball, Texas, United States
Burke Internal Medicine & Research /ID# 202981
🇺🇸Burke, Virginia, United States
Hillcrest Clinics /ID# 202961
🇺🇸Waco, Texas, United States
Tanner Clinic /ID# 168145
🇺🇸Layton, Utah, United States
Advanced Research Institute - Ridgeline /ID# 170445
🇺🇸Ogden, Utah, United States
Velocity Clinical Research - Salt Lake City /ID# 167596
🇺🇸West Jordan, Utah, United States
Physicians Research Options, L /ID# 170441
🇺🇸Draper, Utah, United States
Connecticut Clinical Research Center /ID# 207771
🇺🇸Middlebury, Vermont, United States
Optimum Clinical Research /ID# 170322
🇺🇸Salt Lake City, Utah, United States
Wasatch Peak Family Practice / Synexus Clinical Research US, Inc. /ID# 210175
🇺🇸Layton, Utah, United States
Synexus Clinical Research US, Inc. /ID# 168248
🇺🇸Murray, Utah, United States
Seven Corners Medical Center /ID# 170577
🇺🇸Falls Church, Virginia, United States
Health Research of Hampton Roads, Inc. (HRHR) /ID# 204937
🇺🇸Newport News, Virginia, United States
Virginia Research Center /ID# 170471
🇺🇸Midlothian, Virginia, United States
Northwest Clinical Research Center /ID# 201588
🇺🇸Bellevue, Washington, United States
Clinical Research Associates of Tidewater /ID# 170609
🇺🇸Norfolk, Virginia, United States
Sound Medical Research /ID# 202938
🇺🇸Port Orchard, Washington, United States
Research & Cardiovascular Corp /ID# 170353
🇵🇷Ponce, Puerto Rico
American Health Network of Indiana, LLC /ID# 202987
🇺🇸Greenfield, Wisconsin, United States
Emanuelli Research & Development Center LLC /ID# 206202
🇵🇷Arecibo, Puerto Rico
GCM Medical Group PSC /ID# 170466
🇵🇷San Juan, Puerto Rico
Centro de Endocrinologia Alcantara-Gonzalez /ID# 207260
🇵🇷San Juan, Puerto Rico
Advanced Clinical Research /ID# 170553
🇵🇷Toa Baja, Puerto Rico
VA Nebraska-Western Iowa Health Care System /ID# 167892
🇺🇸Omaha, Nebraska, United States
Heartland Clinical Research /ID# 170541
🇺🇸Omaha, Nebraska, United States
Meridian Clinical Research, LLC - Omaha /ID# 167836
🇺🇸Omaha, Nebraska, United States
Clinical Research Advantage, Inc. /ID# 202966
🇺🇸Omaha, Nebraska, United States
Synexus Clinical Research US Inc /ID# 170560
🇺🇸Omaha, Nebraska, United States
West Florissant Internists /ID# 170314
🇺🇸Bridgeton, Missouri, United States
Allied Clinical Research /ID# 170519
🇺🇸Gold River, California, United States
Wright Clinical Research, LLC /ID# 210864
🇺🇸Alabaster, Alabama, United States
Simon-Williamson Clinic /ID# 210249
🇺🇸Birmingham, Alabama, United States
Alabama Clinical Therapeutics /ID# 202982
🇺🇸Birmingham, Alabama, United States
Cahaba Research, Inc. /ID# 167928
🇺🇸Birmingham, Alabama, United States
Atlanta VAHCS /ID# 170318
🇺🇸Decatur, Alabama, United States
G & L Research, LLC /ID# 170365
🇺🇸Foley, Alabama, United States
Fundamental Research /ID# 170504
🇺🇸Gulf Shores, Alabama, United States
Urology Centers of Alabama /ID# 206197
🇺🇸Homewood, Alabama, United States
Arizona Internal Medicine Specialists, LLC- Glendale /ID# 203011
🇺🇸Glendale, California, United States
Medical Affiliated Research Center, Inc. /ID# 170569
🇺🇸Huntsville, Alabama, United States
Longwood Research /ID# 201754
🇺🇸Huntsville, Alabama, United States
Alaska Urological Institute /ID# 167894
🇺🇸Anchorage, Alaska, United States
Mostellar Medical Center /ID# 170329
🇺🇸Mobile, Alabama, United States
Terence T. Hart, MD /ID# 201561
🇺🇸Tuscumbia, Alabama, United States
Synexus Clinical Research US, INC /ID# 170530
🇺🇸Chandler, Arizona, United States
Fountain Hills Family Practice P.C /ID# 170419
🇺🇸Fountain Hills, Arizona, United States
Horizon Clinical Research Asoc /ID# 202937
🇺🇸Gilbert, Arizona, United States
Lenzmeier Family Medicine /ID# 202945
🇺🇸Glendale, Arizona, United States
Synexus - Desert Clinical Research /ID# 170428
🇺🇸Mesa, Arizona, United States
Phoenix Medical Group, PC /ID# 170516
🇺🇸Peoria, Arizona, United States
Endocrine Assc Long Island PC /ID# 170425
🇺🇸Smithtown, New York, United States
DiGiovanna Institute for Medical Education & Research /ID# 170613
🇺🇸North Massapequa, New York, United States
Office of Bruce R. Gilbert, MD /ID# 202963
🇺🇸Great Neck, New York, United States
Family Practice Specialists /ID# 167859
🇺🇸Phoenix, Arizona, United States
Fiel Family & Sports Medicine /ID# 203034
🇺🇸Tempe, Arizona, United States
Southern Arizona VA Health Care System /ID# 167600
🇺🇸Tucson, Arizona, United States
Eclipse Clinical Research /ID# 170381
🇺🇸Tucson, Arizona, United States
B.G. Clinical Research Center, LLC /ID# 170461
🇺🇸Little Rock, Arkansas, United States
Preferred Research Partners /ID# 170539
🇺🇸Little Rock, Arkansas, United States
Applied Research Center of Arkansas /ID# 170487
🇺🇸Little Rock, Arkansas, United States
Pacific Oaks Medical Group /ID# 170540
🇺🇸Beverly Hills, California, United States
Diagnamics Inc. /ID# 205836
🇺🇸Encinitas, California, United States
West Coast Research LLC /ID# 167903
🇺🇸Dublin, California, United States
Cedars Sinai Medical Group /ID# 170383
🇺🇸Encino, California, United States
S&W Clinical Research /ID# 170311
🇺🇸Fort Lauderdale, Florida, United States
South Florida Research Solutions, LLC /ID# 167972
🇺🇸Hollywood, Florida, United States
Jacksonville Center for Clinical Research /ID# 170446
🇺🇸Jacksonville, Florida, United States
Meridien Research /ID# 167846
🇺🇸Lakeland, Florida, United States
South Florida Wellness & Clinic /ID# 170510
🇺🇸Margate, Florida, United States
Meridian International Research, Inc. /ID# 202975
🇺🇸Miami Lakes, Florida, United States
Office of Francisco G Miranda, /ID# 203184
🇺🇸Miami, Florida, United States
Harmony Clinical Research, Inc. /ID# 201816
🇺🇸North Miami Beach, Florida, United States
Sensible Healthcare /ID# 170402
🇺🇸Ocoee, Florida, United States
San Diego Clinical Trials /ID# 170468
🇺🇸La Mesa, California, United States
TriWest Research Associates- La Mesa /ID# 170498
🇺🇸La Mesa, California, United States
Clinical Trials Research /ID# 210862
🇺🇸Lincoln, California, United States
Accel Research Sites - Tampa Clinical Research Unit /ID# 170377
🇺🇸Tampa, Florida, United States
Tower Urology /ID# 170330
🇺🇸Los Angeles, California, United States
VA Long Beach Healthcare System /ID# 170374
🇺🇸Long Beach, California, United States
Catalina Research Institute, LLC /ID# 170501
🇺🇸Montclair, California, United States
NewportNativeMD, Inc. /ID# 168110
🇺🇸Newport Beach, California, United States
Velocity Clinical Research, Inc. /ID# 168115
🇺🇸North Hollywood, California, United States
Valley Clinical Trials - Northridge Location /ID# 201587
🇺🇸Northridge, California, United States
Valley Renal Medical Group /ID# 170587
🇺🇸Northridge, California, United States
Saviers Medical Group /ID# 170327
🇺🇸Port Hueneme, California, United States
Diabetes Associates Medical Group /ID# 170499
🇺🇸Orange, California, United States
Desert Oasis Healthcare /ID# 170841
🇺🇸Palm Springs, California, United States
Integrated Research Center, Inc. /ID# 170391
🇺🇸San Diego, California, United States
San Diego Sexual Medicine /ID# 170457
🇺🇸San Diego, California, United States
Syrentis Clinical Research /ID# 168056
🇺🇸Santa Ana, California, United States
VA San Diego Healthcare System /ID# 168252
🇺🇸San Diego, California, United States
Care Access Research /ID# 167916
🇺🇸Santa Clarita, California, United States
Encompass Clinical Research /ID# 202203
🇺🇸Spring Valley, California, United States
Olive View UCLA Medical Center /ID# 206131
🇺🇸Sylmar, California, United States
St. Joseph's Medical Associate /ID# 170424
🇺🇸Stockton, California, United States
Millennium Clinical Trials /ID# 210695
🇺🇸Thousand Oaks, California, United States
Anthony Mills, MD, Inc. /ID# 170571
🇺🇸West Hollywood, California, United States
Lynn Institute of Denver /ID# 170312
🇺🇸Aurora, Colorado, United States
Lynn Institute of Colorado Springs South /ID# 168231
🇺🇸Colorado Springs, Colorado, United States
Aventura Heart Center /ID# 170354
🇺🇸Aventura, Florida, United States
Advanced Urology, PLLC dba Colorado Clinical Research /ID# 170406
🇺🇸Lakewood, Colorado, United States
Urology Associates of Colorado /ID# 170484
🇺🇸Englewood, Colorado, United States
New West Physicians /ID# 203032
🇺🇸Golden, Colorado, United States
Lynn Institute of the Rockies /ID# 170477
🇺🇸Colorado Springs, Colorado, United States
MB Clinical Research /ID# 202970
🇺🇸Boca Raton, Florida, United States
Imagine Research of Palm Beach County /ID# 212140
🇺🇸Boynton Beach, Florida, United States
Helix Biomedics, LLC /ID# 202310
🇺🇸Boynton Beach, Florida, United States
Tampa Bay Medical Res, Inc /ID# 170512
🇺🇸Clearwater, Florida, United States
ALL Medical Research /ID# 170493
🇺🇸Cooper City, Florida, United States
Century Clinical Research, Inc /ID# 167597
🇺🇸Daytona Beach, Florida, United States
Seidman Clinical Trials,Delray /ID# 170418
🇺🇸Delray Beach, Florida, United States
Invesclinic, U.S., LLC /ID# 202553
🇺🇸Fort Lauderdale, Florida, United States
Facey Medical Foundation /ID# 203004
🇺🇸Mission Hills, California, United States
Physicians Research Associates, LLC /ID# 170313
🇺🇸Lawrenceville, Georgia, United States
Salem VA Medical Center /ID# 167925
🇺🇸Salem, Virginia, United States
Arizona Research Assoc /ID# 170421
🇺🇸Tucson, Arizona, United States
Quality of Life Medical & Research Center /ID# 167915
🇺🇸Tucson, Arizona, United States
The Center for Diabetes and Endocrine Care /ID# 170373
🇺🇸Fort Lauderdale, Florida, United States
Indago Research and Health Cen /ID# 170420
🇺🇸Hialeah, Florida, United States
The University of Florida Heal /ID# 170450
🇺🇸Jacksonville, Florida, United States
Solutions Through Adv Rch /ID# 201590
🇺🇸Jacksonville, Florida, United States
Health Awareness, Inc - Port St Lucie /ID# 170507
🇺🇸Jupiter, Florida, United States
Care Partners Clinical Research /ID# 202520
🇺🇸Jacksonville, Florida, United States
Quantum Clinical Trials /ID# 224233
🇺🇸Miami Beach, Florida, United States
Masters of Clinical Research, Inc. /ID# 167950
🇺🇸Augusta, Georgia, United States
Well Pharma Medical Research /ID# 170337
🇺🇸Miami, Florida, United States
Applemed Research Inc. /ID# 170364
🇺🇸Miami, Florida, United States
New Horizon Research Center /ID# 170574
🇺🇸Miami, Florida, United States
Medication Management, LLC /ID# 205260
🇺🇸Greensboro, North Carolina, United States
OnSite Clinical Solutions, LLC - Hickory /ID# 202968
🇺🇸Hickory, North Carolina, United States
PMG Research of Piedmont Healthcare /ID# 170341
🇺🇸Mooresville, North Carolina, United States
PMG Research of Wilmington LLC /ID# 170492
🇺🇸Wilmington, North Carolina, United States
International Research Associates, LLC /ID# 170543
🇺🇸Miami, Florida, United States
International Research Associates, LLC /ID# 170563
🇺🇸Miami, Florida, United States
Bravo Health Care Center /ID# 202201
🇺🇸North Bay Village, Florida, United States
Endocrine Associates of Florida, P.A. /ID# 167839
🇺🇸Ocoee, Florida, United States
DBC Research Corp /ID# 170435
🇺🇸Tamarac, Florida, United States
IMIC Inc. Medical Research /ID# 167899
🇺🇸Palmetto Bay, Florida, United States
South Broward Research /ID# 170480
🇺🇸Pembroke Pines, Florida, United States
Synexus Clinical Research US, Inc /ID# 209955
🇺🇸Pinellas Park, Florida, United States
DBC Research USA /ID# 170332
🇺🇸Pembroke Pines, Florida, United States
DMI Research, Inc. /ID# 170893
🇺🇸Pinellas Park, Florida, United States
Charlotte Heart & Vascular Institute /ID# 202965
🇺🇸Port Charlotte, Florida, United States
Clinical Research Center FL /ID# 202979
🇺🇸Pompano Beach, Florida, United States
St. Johns Center /ID# 212654
🇺🇸Ponte Vedra, Florida, United States
Endocrine Consustants Research /ID# 168147
🇺🇸Columbus, Georgia, United States
Accel Research Sites - St Petersburg Clinical Research Unit /ID# 170370
🇺🇸Saint Petersburg, Florida, United States
Professional Health Care of Pinellas /ID# 167895
🇺🇸Saint Petersburg, Florida, United States
Advance Medical Research /ID# 170532
🇺🇸Saint Petersburg, Florida, United States
St. Jude Hospital Yorba Linda /ID# 170437
🇺🇸Fullerton, California, United States
Marvel Clinical Research, LLC /ID# 170324
🇺🇸Huntington Beach, California, United States
Bayview Research Group LLC /ID# 203036
🇺🇸Valley Village, California, United States
Clinical Research Advantage, Inc. /ID# 170656
🇺🇸Evansville, Indiana, United States
Research Integrity, LLC /ID# 168264
🇺🇸Owensboro, Kentucky, United States
First Urology,PSC /ID# 167719
🇺🇸Jeffersonville, Indiana, United States
Aventiv Research Columbus /ID# 170338
🇺🇸Columbus, Ohio, United States
WVVA Healthcare Alliance dba. /ID# 168246
🇺🇸Lewisburg, Ohio, United States
MidLantic Urology /ID# 170351
🇺🇸Bala-Cynwyd, Pennsylvania, United States
Family Medicine Associates of Texas, PA /ID# 167849
🇺🇸Carrollton, Texas, United States
DiscoveResearch, Inc. /ID# 170320
🇺🇸Beaumont, Texas, United States
Synexus Clinical Research US, INC /ID# 170319
🇺🇸Dallas, Texas, United States
East Texas Cardiology /ID# 170638
🇺🇸Houston, Texas, United States
PrimeCare Medical Group /ID# 168146
🇺🇸Houston, Texas, United States
Associates in Medicine, P.A. /ID# 170439
🇺🇸Houston, Texas, United States
Texas Center for Drug Development, Inc. /ID# 170404
🇺🇸Houston, Texas, United States
Research Trials Worldwide /ID# 210694
🇺🇸Humble, Texas, United States
Synexus Research - San Antonio /ID# 202947
🇺🇸San Antonio, Texas, United States
Spring Family Practice Associates, PA /ID# 203470
🇺🇸Spring, Texas, United States
Precision Clinical Research /ID# 170469
🇺🇸Sunrise, Florida, United States
Stanford University /ID# 167595
🇺🇸Redwood City, California, United States
Winter Park Urology Center/Charter Research /ID# 210542
🇺🇸Winter Park, Florida, United States
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center /ID# 170400
🇺🇸Torrance, California, United States
3rd Coast Research Associates /ID# 203091
🇺🇸Corpus Christi, Texas, United States
Triad Clinical Trials /ID# 170376
🇺🇸Greensboro, North Carolina, United States
Innovative Research of West Florida /ID# 170360
🇺🇸Clearwater, Florida, United States
Hillcroft Medical Clinic /ID# 170500
🇺🇸Sugar Land, Texas, United States
Family Medical Associates /ID# 170396
🇺🇸Levittown, Pennsylvania, United States
Consano Clinical Research, LLC /ID# 167848
🇺🇸Shavano Park, Texas, United States
MediSphere Medical Research Center /ID# 170317
🇺🇸Evansville, Indiana, United States
Optimed Research, Ltd. /ID# 168111
🇺🇸Columbus, Ohio, United States
Protenium Clinical Research /ID# 170397
🇺🇸Hurst, Texas, United States
Torrance Clinical Research Institute, Inc. /ID# 170307
🇺🇸Lomita, California, United States
St. Louis University /ID# 170531
🇺🇸Saint Louis, Missouri, United States
American Health Network of Indiana, LLC /ID# 170578
🇺🇸Muncie, Indiana, United States
Meridien Research Inc. - Brooksville /ID# 170556
🇺🇸Brooksville, Florida, United States
Atlanta Center for Clinical Research /ID# 202984
🇺🇸Roswell, Georgia, United States
Meridian Clinical Research LLC /ID# 167854
🇺🇸Savannah, Georgia, United States
Meridian Clinical Research LLC /ID# 170548
🇺🇸Savannah, Georgia, United States
LaPorte County Institute for Clinical Research, Inc. /ID# 170331
🇺🇸Michigan City, Indiana, United States
Awasty Research Network, LLC /ID# 210860
🇺🇸Marion, Ohio, United States
Mercy Health St. Vincent Medical Center, LLC, Clinical Research Office /ID# 203035
🇺🇸Toledo, Ohio, United States
Indiana-Armstrong Endocrinolgy /ID# 168249
🇺🇸Indiana, Pennsylvania, United States
Richard M Kastelic, MD and Ass /ID# 170382
🇺🇸Johnstown, Pennsylvania, United States
Allegheny Health Network /ID# 210544
🇺🇸Pittsburgh, Pennsylvania, United States
Synexus Clinical Research US, Inc. /ID# 210228
🇺🇸Anderson, South Carolina, United States
SFM Clinical Trials /ID# 168250
🇺🇸Scotland, Pennsylvania, United States
Universal Research Group, LLC /ID# 170442
🇺🇸Tacoma, Washington, United States
Irvine Center for Clinical Research /ID# 170368
🇺🇸Irvine, California, United States
Alas Science Clinical Research /ID# 170352
🇺🇸Henderson, Nevada, United States
Center for Clinical Trials of Sacramento, Inc. /ID# 168108
🇺🇸Sacramento, California, United States
Omega Research Group /ID# 170340
🇺🇸Orlando, Florida, United States
University of Louisville /ID# 170607
🇺🇸Louisville, Kentucky, United States
Medical Research South, LLC /ID# 203068
🇺🇸Charleston, South Carolina, United States
East-West Medical Research Institute /ID# 202959
🇺🇸Honolulu, Hawaii, United States
James J. Peters VA Medical Center /ID# 202980
🇺🇸Bronx, New York, United States
University of Florida - Hull Rd /ID# 170518
🇺🇸Gainesville, Florida, United States
Malcom Randall VAMC /ID# 170645
🇺🇸Gainesville, Florida, United States
Tulane School of Medicine /ID# 170472
🇺🇸New Orleans, Louisiana, United States
Premier Family Physicians /ID# 167946
🇺🇸Austin, Texas, United States
Hunter Holmes McGuire VA Medical Center /ID# 170630
🇺🇸Richmond, Virginia, United States
Clinical Research Partners LLC - Richmond Forest Ave /ID# 170490
🇺🇸Richmond, Virginia, United States
Drs. Borders, Hood, and Assoc /ID# 170536
🇺🇸Lexington, Kentucky, United States
The Research Grp of Lexington /ID# 202900
🇺🇸Lexington, Kentucky, United States
NM Clinical Research & Osteoporosis Center, Inc /ID# 170386
🇺🇸Albuquerque, New Mexico, United States
PMG Research of Charlotte /ID# 202985
🇺🇸Charlotte, North Carolina, United States
OnSite Clinical Solutions, LLC /ID# 170349
🇺🇸Charlotte, North Carolina, United States
University of Tennessee Health /ID# 170321
🇺🇸Memphis, Tennessee, United States
Methodist Medical Group /ID# 168148
🇺🇸Memphis, Tennessee, United States
Clinical Investigation Specialists, Inc. /ID# 170631
🇺🇸Gurnee, Illinois, United States
Deaconess Clinic Downtown /ID# 167855
🇺🇸Evansville, Indiana, United States
The Iowa Clinic, PC /ID# 202986
🇺🇸West Des Moines, Iowa, United States
AccuMed Research Associates /ID# 202200
🇺🇸Garden City, New York, United States
Pioneer Research Solutions, Inc. /ID# 168062
🇺🇸Beaumont, Texas, United States
Manassas Clinical Research Center /ID# 201815
🇺🇸Manassas, Virginia, United States
ClinRx Research, LLC /ID# 203067
🇺🇸Plano, Texas, United States
Synexus Clinical Research US, Inc. /ID# 210293
🇺🇸Jamaica, New York, United States
Randolph Health Internal Medicine /ID# 168227
🇺🇸Asheboro, North Carolina, United States
Hill Country Medical Assoc /ID# 170444
🇺🇸New Braunfels, Texas, United States
Centex Studies, Inc /ID# 203019
🇺🇸McAllen, Texas, United States