JPRN-C000000083已完成3 期
Randomized controlled trial comparing ciprofloxacin and cefepime in febrile neutropenic patients with hematologic diseases (C-SHOT 0402 study) - RCT comparing CPFX and CFPM in febrile neutropenic patients with hematologic diseases (C-SHOT 0402 study)
Center for Supporting Hematology-Oncology Trials (C-SHOT)0 个研究点目标入组 200 人开始时间: 2005年8月29日最近更新:
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 200
研究概览
简要总结
Fifty-one episodes were included in this trial, and 49 episodes (CPFX vs. CFPM: 24 vs. 25) were evaluated. Treatment efficacy at day 7 was significantly higher in the CFPM group (successful clinical response: nine with CPFX and 19 with CFPM; p=0.007). The response was better in high-risk patients with neutrophil counts of less or equal to 100/microliter (p=0.003). The overall response during the study period was similar between the CPFX and CFPM groups (p=0.64). Adverse events were minimal, and all patients could continue the treatment.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 15years-old 至 80years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •(1) Past history of allergic reaction to the study drug (2) Positive for HIV antibody (3) Pregnant or lactating woman (4) Family history of auditory disturbance (5) Having received systemic antibacterial therapy within 14 days (6) Receiving systemic antifungal or antiviral therapy except fluconazole or acyclovir for cases undergoing transplantation (7) No recovery of neutrophil count of 1,000/microL or higher from the previous febrile episode (8) On treatment with ketoprofen (9) On treatment with sodium valproate (10) Septic shock
研究者
相似试验
已完成
3 期
Comparing Ciprofloxacin (CPFX) With Cefepime (CFPM) in Febrile Neutropenic Patients With Hematologic DiseasesFebrile NeutropeniaNCT00137787Center for Supporting Hematology-Oncology Trials51
已完成
不适用
PROSPECTIVE, RANDOMIZED STUDY TO COMPARE CIPROFLOXACIN (IN ORAL SUSPENSION, IV SEQUENTIAL TREATMENT, ORAL SUSPENSION OR EXCLUSIVELY IV) VERSUS ESTABLISHED COMPARATIVE REGIMES (EITHER CEFIXIME ORAL SUSPENSION, SEQUENTIAL TREATMENT WITH CEFTAZIDIME IV -> CEFIXIMA ORAL SUSPENSION OR CEFTAZIDIME EXCLUSIVELY IV) FOR THE TREATMENT OF PEDIATRIC PATIENTS WITH COMPLICATED INFECTIONS OF THE URINARY TRACT OR PIELONEFRITIS.-N390 Urinary tract infection, site not specifiedUrinary tract infection, site not specifiedN390PER-019-01BAYER S.A.,
已完成
3 期
Single Dose Ciprofloxacin in the Treatment of Childhood Cholera:Randomized Controlled Clinical TrialCholeraNCT00142272International Centre for Diarrhoeal Disease Research, Bangladesh180
已完成
2 期
Finafloxacin 300 mg Twice a Day (b.i.d.) Versus Ciprofloxacin 250 mg Twice a Day (b.i.d) in Patients With Lower Uncomplicated UTI (uUTI)Urinary Tract InfectionsNCT00722735MerLion Pharmaceuticals GmbH36
已完成
不适用
A randomised comparison of ciprofloxacin, levofloxacin and gatifloxacin for the treatment of adults with tuberculous meningitisInfections and InfestationsTuberculous meningitisISRCTN07062956niversity of Oxford (UK)