Effect of Repetitive Transcranial Magnetic Stimulation in Vascular Parkinsonism
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Vascular Parkinsonism
- Sponsor
- Inje University
- Enrollment
- 32
- Locations
- 1
- Primary Endpoint
- Unified Parkinson's Disease Rating Scale (UPDRS) part III-motor part (Number 18 ~31 of UPDRS)
- Status
- Not yet recruiting
- Last Updated
- 7 years ago
Overview
Brief Summary
Vascular parkinsonism (VP), parkinsonism resulting from ischemic cerebrovascular disease, was suggested in 1929. The main features are wide-based gait, postural instability, and falls, which make patients with VP frustrated. Currently, the treatment is challenging.
Transcranial magnetic stiumation is a noninvasive procedure using electromagnetic induction to stimulate brain, and repetitive transcranial magnetic stiumation (rTMS) can selectively change brain activity to enhance desired effects. The aim of this study is to explore the therapeutic effect of rTMS for the VP.
Investigators
Sangjin Kim
Professor
Inje University
Eligibility Criteria
Inclusion Criteria
- •Vascular parkinsonism
- •age 18 and older
Exclusion Criteria
- •pregnant or any, other medical, surgical, neurological or psychiatric conditions
- •other restrictions which prevent you from undergoing TMS recording, such as; surgically or traumatically implanted foreign bodies such as a pacemaker, an implanted medication pump, a metal plate in the skull, or metal inside the skull or eyes (other than dental appliances or fillings), and/ or heart/cardiac lines
- •any past or current history of seizure disorder or epilepsy
- •unable to give informed consent
Outcomes
Primary Outcomes
Unified Parkinson's Disease Rating Scale (UPDRS) part III-motor part (Number 18 ~31 of UPDRS)
Time Frame: 2 days
Motor functions will be checked using UPDRS. Each item of the motor part ranges from 0 to 4 (0 means normal, 4 means worst condition). Total sum will be calculated.
Secondary Outcomes
- The total number of steps during the stand-walk-sit (SWS) test(2 days)
- Freezing episodes of gait trajectory(2 days)
- Finger tapping test with right hand(2 days)
- The completion time during the SWS test(2 days)
- Patient and Clinical Global Impression Scale(2 days)