Randomized Evaluation of Carotid Occlusion and Neurocognition (RECON)

Columbia University1 site in 1 country294 target enrollmentNovember 2004

ConditionsCarotid Artery Diseases

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Carotid Artery Diseases
Sponsor: Columbia University
Enrollment: 294
Locations: 1
Primary Endpoint: Cognitive Functioning on Neuropsychological assessment measures
Status: Completed
Last Updated: 12 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

To determine the relationship between cognitive functioning and blood flow in the brain among patients randomized to either extracranial-intracranial (EC-IC) bypass or medical therapy alone in the Carotid Occlusion Surgery Study (COSS).

Detailed Description

The Carotid Occlusion Surgery Study (COSS) evaluates whether a surgical operation, EC-IC bypass surgery, can reduce the chance of a stroke in someone who has complete blockage in one main artery in the neck that supplies blood to the brain (the carotid artery). The operation bypasses the blockage so more blood can flow to the brain. Only people with decreased blood flow to the brain, as demonstrated on a PET (positron emission tomographic) scan, are randomized into the COSS study. Among patients randomized into the COSS study, RECON will evaluate whether restoring the blood flow to the brain (with EC-IC bypass surgery) will also improve mental functioning. Participants in both the surgical and medical groups of the COSS study will participate in the RECON study. By comparing the mental functioning of the participants in both treatment groups over the course of 2 years, the investigators hope to determine whether the EC-IC bypass operation also helps improve or maintain mental functioning.

Registry

clinicaltrials.gov

Start Date

November 2004

End Date

June 2012

Last Updated

12 years ago

Study Type

Interventional

Study Design

Parallel