Effects of inducing and maintaining anaesthesia with propofol on blood pressure and the body's own renin-angiotensin-aldosterone system in normal weight and obese children and adolescents

• Conditions: E66.9; Obesity, unspecified

• Registration Number: DRKS00021667
• Lead Sponsor: niversitätsklinikum Leipzig AöR; Klinik und Poliklinik für Anästhesiologie und Intensivtherapie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2013-08-14
• Study Start: 2020-05-07
• Results First Posted: 2020-07-06
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 59

Inclusion Criteria

Consent of legal guardians; anaesthesia in the operative field of paediatric surgery/orthopaedics; ASA I + II; operation time > 45 min

Exclusion Criteria

rejection by legal guardians; ASA III + IV; requirement for rapid sequence induction; intraoperative administration of catecholamines; long-term therapy with steroids, opioid analgesics and/or sedatives; tumor diseases; participation in another clinical study; critically ill child (intensive care); presence of pregnancy

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The aim of the study is to investigate the influence of propofol on blood pressure and on various endogenous hormonal regulatory mechanisms (renin-angiotensin-aldosterone system, vasopressin system, catecholamines) in children and adolescents as a function of BMI.

Secondary Outcome Measures

Name	Time	Method
A further aim is to clarify whether overweight or obese children/adolescents have less or more blood pressure drops than normal weight patients during general anaesthesia with Propofol?<br>For this purpose, the non-invasive blood pressure values regularly measured during general anaesthesia are evaluated.