Use of a Remifentanil-propofol Mixture in Patients With Breast Cancer Undergoing Breast Cancer Surgery: a Prospective Pilot Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Anesthetics
- Sponsor
- Tri-Service General Hospital
- Enrollment
- 84
- Locations
- 1
- Primary Endpoint
- Frequency of TCI device adjustments
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Co-administration of propofol and remifentanil is considered to be an ideal total intravenous anesthesia technique, which is widely used in induction and maintenance of general anesthesia. Remifentanil and propofol can be mixed in polypropylene syringes for one hour with a remaining concentration of 91% in small concentrations of remifentanil. However, delivery of remifentanil-propofol mixture by target-controlled infusion(TCI) for general anesthesia in surgical procedure has not been described. Breast cancer surgery ( including modified radical mastectomy and breast-conserving surgery) is a less time-consuming procedure for patients with breast cancer with one-hour duration in our hospital. This pilot study was to examine the merit of remifentanil-propofol mixture as a GA regimen for breast cancer surgery.
Detailed Description
Previous studies has described the feasibility and safety of remifentanil-propofol mixture use in sedation of pediatric patients undergoing magnetic resonance imaging or flexible fiberoptic bronchoscopy.
Investigators
Meng-Fu Lai
Resident physician
Tri-Service General Hospital
Eligibility Criteria
Inclusion Criteria
- •ASA II or III
- •age more than 18 years
- •scheduled for breast cancer surgery under general anesthesia.
Exclusion Criteria
- •previously allergic to propofol or remifentanil
- •combining other surgical procedure leading to extended operative time
Outcomes
Primary Outcomes
Frequency of TCI device adjustments
Time Frame: during procedure
Total times of TCI pump adjustment
Secondary Outcomes
- Mean blood pressure(at 5 minute intervals perioperatively throughout the procedure in an average of 60 minutes)
- Patient satisfaction(the 1 day after operation)
- postoperative analgesia rescue(An average of 30 minutes after arriving at PACU)
- Total dose of remifentanil(At the end of surgery)
- Heart rate(at 5 minute intervals perioperatively throughout the procedure in an average of 60 minutes)
- Total dose of propofol(At the end of surgery)