Effect of Non Surgical Periodontal Therapy on Levels of Il-17 and Il-18 in Chronic Periodontitis Patients Versus Periodontally Healthy Individuals
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- measure levels of Il-17 and Il-18 in chronic periodontitis patients
研究概览
简要总结
The current study was performed to study levels of Il-17 and Il-18 in aggressive periodontitis patients before and after non surgical periodontal therapy
详细描述
Background:host defense factors are involved in pathogenesis of chronic periodontitis so, the current study is assessing levels of Il-17 and Il-18 in chronic periodontitis patients versus periodontally healthy controls.
Subjects and methods: Fifty subjects were included; twenty five of them are diagnosed with chronic periodontitis patients and twenty five are periodontally healthy subjects. Probing depth (PD), clinical attachment level (CAL), plaque index (PI) and gingival index (GI) were recorded for all the enrolled subjects. GCF levels of Il-17 and IL-18 were analyzed by enzyme-linked immunosorbent assay (ELISA).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Medically free subjects .
- •both genders .
- •age range between 30 to 60 years old .
排除标准
- •Subjects with periodontal surgeries in the last 6 months.
- •Subjects with prior use of antibiotics in the last 6 months.
- •Pregnant and lactating females were excluded.
- •Lactating females.
结局指标
主要结局
measure levels of Il-17 and Il-18 in chronic periodontitis patients
时间窗: Change from Baseline Il-17 andIl-18 at 3 months
measure levels of Il-17 and Il-18 in GCF of chronic periodontitis patients
次要结局
未报告次要终点
研究者
Sarah Elkot
Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo, Egypt.
Future University in Egypt