Effects of Synchronised Auditory Stimulations of the Sleep Slow Oscillation on Deep Sleep
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- Dreem
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Variation of the amplitude of sleep slow oscillations
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
This monocentric, cross-over, randomised, double blind and placebo-controlled study evaluates the effects of auditory stimulations of the sleep slow oscillation on deep sleep quality.
Detailed Description
Sleep quality impairment has long been identified as a risk factor to develop cardio-vascular, metabolic and more recently neurodegenerative diseases. The slow wave sleep, characterized by slow oscillations, has a major role on memory and hormones releasing. Here, we aim to assess a miniaturized sleep device that would automatically detect and stimulate sleep slow oscillations with sounds to enhance deep sleep quality. The subjects realize 3 conditions : * Up condition : Auditory stimulations are delivered in synchrony with the up phase of slow oscillations during N3 sleep stage. * Random condition : Auditory stimulations are randomly delivered during N3 sleep stage. * Placebo condition: The device is worn without any auditory stimulations delivered. The subjects are equipped with a reference polysomnography and the auditory stimulation device during 3 nights and one habituation night prior to them. A wash out period of 6 days between each night will be respected.
Investigators
Eligibility Criteria
Inclusion Criteria
- •healthy subject
- •moderate morningness, intermediate or moderate eveningness chronotype (Horne \& Östberg questionnaire)
Exclusion Criteria
- •sleep disorder according to the ICSD-3 or DSM-5
- •travelling away from more than a time zone in the previous month
- •acute or chronic disorders (cardio-vascular, respiratory, neurologic, psychiatric)
- •night shifts work
- •smoking more than 5 cigarettes per day
- •drinking more than 5 glass of alcohol per week
- •consuming excessive drinks with xanthics (coffee, tea, coke more than 6 cups per day).
- •having a body mass index \>30kg.m -2
- •being pregnant
Outcomes
Primary Outcomes
Variation of the amplitude of sleep slow oscillations
Time Frame: 3 days
Amplitude of sleep slow oscillation assessed during N3 sleep stages throughout 3 separate nights. The analysis is based on electroencephalography signal.
Secondary Outcomes
- Variation of the number of remembered words in declarative memory tasks (word pair task)(3 days)
- Variation of mood assessment measured with the profile of mood scale (POMS)(3 days)
- Variation of mental rotation capacity (mental rotatory task)(3 days)
- Variation of N3 sleep stage duration(3 days)
- Variation of subjective sleepiness measured with the Karolinska sleepiness scale (KSS)(3 days)
- Variation of the number of sleep slow oscillations(3 days)
- Variation of average response time variation and omissions in the Psychomotor vigilance task (PVT)(3 days)
- Variation of salivary cortisol concentration(3 days)
- Variation of salivary testosterone concentration(3 days)