Which muscles are critical for abnormal posture, balance and gait in patients with FSHD?

Recruiting

Conditions: facioscapulohumeral dystrophy / Landouzy-Dejerine syndrome
10028302

Registration Number: NL-OMON34404

Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

- Diagnosis FSHD based on a positive (family) history, examination, genetically confirmed.
- Age between 18-80 years.
- Being able to stand independently and walk for ten meters without aids.

Exclusion Criteria

- Other neurological or musculoskeletal disorders.
- Use of medication affecting balance (e.g. neuroleptics, antidepressants, anticonvulsants).

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Maximum EMG amplitude, expressed as a percentage of the MVC during isolated<br /><br>contraction, is the primary outcome measure of the posture, balance and gait<br /><br>tasks.<br /><br>For the MRIS measurements, the primary outcome will be the cross-sectional area<br /><br>of the various leg and trunk muscles.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Posture: the joint angles of the lower back, hips, knees, and ankles in two<br /><br>positions.<br /><br>Gait: gait velocity; spatiotemporal variables (e.g. step lengths and cadence);<br /><br>joint angles and joint torques of the lower back, hips, knees and ankles during<br /><br>the gait cycle.<br /><br>Balance: spatiotemporal variables (e.g. displacement of the centre of mass)<br /><br>joint angles and joint torques.<br /><br>MRI: fatty degeneration on a four point scale proposed by Lamminen (1990).</p><br>