A Study of the Trajectory of Overall Systemic Health Outcomes and Potential Complications in Recovered COVID-19 Patients.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 17,000
- 试验地点
- 1
- 主要终点
- Changes in laboratory examination indicators
研究概览
简要总结
Clarify the incidence of functional impairments in cured COVID-19 patients and identify influencing factors. Build a multi-omics database for COVID-19 patients in the recovery period to elucidate the biological biomarkers and targets associated with functional impairments. Comprehensive exploration of the long-term prognosis, complications, sequelae, and risk factors of COVID-19 patients after Omicron infection, as well as their immune characteristics. Compare the impact of different strains of the COVID-19 virus on prognosis and immune response. Develop comprehensive rehabilitation intervention strategies for COVID-19 patients with functional impairments and evaluate the impact of different intervention methods on their prognosis. Based on clinical data, multi-omics data, and precise rehabilitation assessment data, construct predictive models for prognosis and rehabilitation effectiveness in COVID-19, providing scientific evidence for the implementation of effective COVID-19 rehabilitation measures.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 120 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Meets the diagnostic criteria for confirmed cases according to the "Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 10)";
- •The participant or the authorized representative understands the entire purpose of the study, voluntarily participates in the research, and signs an informed consent form, ensuring that they can complete regular assessments at the relevant participating units and receive necessary rehabilitation treatment as required;
- •Agrees to the researcher's collection of their peripheral blood samples, saliva samples, and urine samples for the needs of the study.
排除标准
- •Women who are pregnant or breastfeeding;
- •Individuals with mental disorders that affect normal communication;
- •Those who refuse to participate in regular assessments and rehabilitation treatments;
- •Individuals who decline to provide specimens required for the study.
结局指标
主要结局
Changes in laboratory examination indicators
时间窗: 6 months, 12 months and 24 months
Pulmonary function test
时间窗: 3 months, 12 months
Inflammatory factors related to body dysfunction in COVID-19 rehabilitation patients
时间窗: 6 months, 12 months and 24 months
Immunological characteristics associated with functional impairments in COVID-19 convalescent patients
时间窗: 6 months, 12 months and 24 months
Regular rehabilitation assessment following respiratory rehabilitation intervention in COVID-19 patients
时间窗: 6 months, 12 months and 24 months
Multi-omics changes and characteristics associated with functional impairments in COVID-19 convalescent patients
时间窗: 6 months, 12 months and 24 months
High-resolution CT of the chest
时间窗: 6 months, 12 months and 24 months
次要结局
未报告次要终点
研究者
Zhaohui Tong
professor
Capital Medical University