Parasite Clearance of Two Commonly Administered Artemisinin-Based Combination Therapies in Under-Five Children With Uncomplicated Malaria at Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife.

Not Applicable

• Conditions: Malaria; Paediatrics

• Registration Number: PACTR202007553348930
• Lead Sponsor: Ahmed Abdulakeem

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-06-15
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 122

Inclusion Criteria

(i)All patients between the age of 6 month and 59 months with signs and symptoms of acute uncomplicated malaria.
(ii)Axillary temperature =37.5 ºC or history of fever during the past 24 hr.
(iii)Ability to swallow oral medication.
(iv)Microscopically confirmed asexual forms of P. falciparum with parasite density count of between 2000 and 200 000 parasites / µl.
(v)Willingness of the parent/guardian to comply with protocol as regards the study visit schedule.

Exclusion Criteria

(i)Those having symptoms and signs of severe falciparum malaria.
(ii)A febrile condition due to diseases other than malaria e.g. measles, acute lower respiratory tract infection.
(iii)Patients having severe malnutrition.
(iv) Patients with sickle cell anaemia.
(v)History of use of medication such as erythromycin, azithromycin, clindamycin and Septrin that might interfere with antimalarial pharmacokinetics.
(vi)History of hypersensitivity to any of the study drugs will be excluded from the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified