The Feasibility of Propofol TCI in Hemodialysis Patients Undergoing Arteriovenous Shunt Surgery
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- Change in blood pressure
研究概览
简要总结
Written informed consent must be obtained before any study specific procedures are undertaken. Informed consent will be obtained during pre-operative assessment.
详细描述
The investigators will recruit 80 patients undergoing AV shunt surgery. All patients will receive general anesthesia and brachial plexus block. Patients will be randomly allocated into two groups. Study and control group received propofol target-controlled infusion (TCI) and inhaled anesthetics as anesthesia maintenance, respectively. Main outcomes will be assessed by perioperative blood pressure, heart rate, respiratory rate, end-tidal CO2, analgesics dosage, pain intensity and perioperative adverse events.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Uremic adult(over20-year-old)patients under going arteriovenous (AV) shunt surgery
排除标准
- •one of below systemic diseases; chronic pulmonary, cardiac diseases(such as COPD, asthma, acute myoischemia), hepatic co-mobility(such as liver cirrhosis), morbid obesity, alcoholism, allergy to propofol and inhaled anesthetics, the women who are pregnant or breastfeeding
研究组 & 干预措施
Propofol group
propofol TCI plus brachial plexus block with ropivacaine 0.5% 30 to 40 ml
干预措施: Propofol (Drug)
Sevoflurane group
sevoflurane 2~4 % plus brachial plexus block with ropivacaine 0.5% 30 to 40 ml
干预措施: Sevoflurane (Device)
结局指标
主要结局
Change in blood pressure
时间窗: The blood pressure change between baseline, post-induction 3mins, operation start, post-operation 10 mins,post-operation 30 mins,post-operation 1 hour,post-operation 2 hours, end of surgery, recovery room, up to 4 hours
Systolic blood pressure, diastolic blood pressure
次要结局
- analgesics dosage(The amount of analgesics dosage use at recovery room,an average of 4 hours)
- Change in pain intensity(The pain intensity change at recovery room, post-operation day 1, post-operation day 2)