inflAmmatory maRkers in Blood and Thrombus Aspirated From Patients With acutE myocaRdial Infarction With St-segment elevAtion

Fundación Canaria Rafael Clavijo para la Investigación Biomédica1 site in 1 country100 target enrollmentNovember 2012

ConditionsPatients Admitted With the Diagnosis of ST-elevation Acute Coronary Syndrome

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Patients Admitted With the Diagnosis of ST-elevation Acute Coronary Syndrome
Sponsor: Fundación Canaria Rafael Clavijo para la Investigación Biomédica
Enrollment: 100
Locations: 1
Primary Endpoint: The primary objective of the study is to find out whether there is an association between certain inflammatory markers in blood and intracoronary thrombus and whether these markers are associated with the composite of all-cause mortality
Last Updated: 13 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The prognostic value of inflammatory markers in acute coronary syndrome has been extensively demonstrated, however it is still unknown whether there is an association between circulating and local (thrombus) inflammatory molecules, and the subset of molecules that provide better prognostic information in patients with ST-elevation acute coronary syndrome.

Registry

clinicaltrials.gov

Start Date

November 2012

End Date

November 2013

Last Updated

13 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Fundación Canaria Rafael Clavijo para la Investigación Biomédica

Responsible Party

Principal Investigator

Enrique Quintero

Alberto Dominguez Rodriguez

Fundación Canaria Rafael Clavijo para la Investigación Biomédica

Eligibility Criteria

Inclusion Criteria

•They include patients of both sexes, without limits of age, with a diagnosis of STEMI within 12 hours after the beginning of symptoms. ST-elevation myocardial infarction was defined in the presence of symptoms consistent, persistent elevation (\> 20 min) ST segment ≥ 1 mm in at least two contiguous leads or in the presence of left bundle branch block presumably new onset and cardiac troponin I elevation

Exclusion Criteria

•Injury significant common core of left coronary artery (stenosis greater than or equal to 50% of the vessel lumen).
•Pre-Fibrinolysis percutaneous coronary intervention.
•Previous coronary bypass surgery.
•Thyrotoxicosis.
•Having an inflammatory systemic or local inflammatory process.
•Malignant neoplasm.
•Any disease that seriously compromise the prognosis and / or systemic inflammatory response generated.
•No thrombotic material obtained in the thrombus or insufficient for performing biochemical determinations.

Outcomes

Primary Outcomes

The primary objective of the study is to find out whether there is an association between certain inflammatory markers in blood and intracoronary thrombus and whether these markers are associated with the composite of all-cause mortality

Time Frame: one year