Intravesical Lactobacillus for Urinary Symptoms Among People with NLUTD Who Use Indwelling Catheters
- Conditions
- Neurogenic Bladder
- Interventions
- Drug: Culturelle 10 Billion CFU Capsule
- Registration Number
- NCT04323735
- Lead Sponsor
- Medstar Health Research Institute
- Brief Summary
The objectives of the proposed research among this population are: 1) to define clinically meaningful change (i.e. differentiating states of health and illness) with respect to urinary symptoms, urine inflammation, cultivable bacteria, and the urine ecosystem; and 2) to determine the optimal intravesical Lactobacillus RhamnosusGG (LGG®) dose to be used to reduce urinary symptoms in a future clinical trial.
- Detailed Description
Urinary tract infection (UTI) is the most common outpatient infection world-wide, and for people with spinal cord injury (SCI) and neurogenic bladder (NB), it is the most common infection, secondary condition, cause for emergency room visits, and infectious cause of hospitalization. Despite its prevalence, attempts to ameliorate UTI among people with SCI are stymied by long-standing diagnostic challenges which arise from evidence gaps around "gold standard" diagnostic tests (urinalysis and urine culture) that have lower sensitivity and specificity for UTI in this population. A high prevalence of chronic inflammation leading to persistence of white blood cells (WBC) in the urine confounds the utility of WBC count, pyuria, and leukocyte esterase as biomarkers for UTI; nitrites in urine indicate the presence of only specific (but not all) organisms, many of which are present to a greater extent in the urine of people with SCI; and people with SCI have a high prevalence of asymptomatic bacteriuria. These physiologic changes render the gold standard diagnostic tests less useful for identifying UTI in persons with SCI.
SA1. Estimate healthy, asymptomatic state variability of urine NGAL (uNGAL), white blood cells (uWBC), nitrite, cultivable bacteria, and the urinary microbiome.
SA2. Estimate the effect of intravesical LGG dose on urinary symptoms (primary outcome), uNGAL, uWBC, nitrites, cultivable bacteria, and the urine microbiome (secondary outcomes).
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 182
- Neurogenic bladder for at least 6 months;
- Utilizing indwelling catheterization for bladder management;
- Women must be premenopausal and not currently menstruating;
- Community dwelling
- physical disability
- Use of prophylactic antibiotics;
- Instillation of intravesical antimicrobials to prevent UTI;
- Psychologic or psychiatric conditions influencing the ability to follow instructions;
- Use of oral or IV antibiotics within the past 2 weeks;
- Sexual activity within the previous 72 hours;
- Participation in another study with which results could be confounded.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Low Dosage Culturelle 10 Billion CFU Capsule For the LGG® instillation, participants will be instructed to mix the contents of 1 LGG capsule into 45 cc sterile 0.9% saline. After mixing, participants will draw up the 45cc liquid LGG mixture into a 60cc syringe and instill via the indwelling catheter (the catheter will not be changed as this would represent 2 interventions). Participants will be instructed the plug their catheter for 1 hour. Participants will receive 2 \]LGG capsules and will repeat this process the following day ("Low" dose). Subjects will remain in the study for up to 29 months, with participation ending after one completed intervention (2 doses) and post-intervention assessments are complete. If urinary symptoms do not occur warranting instillation during the ensuing 29 months, participants will be asked to return any remaining kits (including LGG®). Participants will be instructed to complete the USQNB-IDC weekly until study completion. High dosage Culturelle 10 Billion CFU Capsule For the LGG® instillation, participants will be instructed to mix the contents of 1 LGG capsule into 45 cc sterile 0.9% saline. After mixing, participants will draw up the 45cc liquid LGG mixture into a 60cc syringe and instill via the indwelling catheter (the catheter will not be changed as this would represent 2 interventions). Participants will be instructed the plug their catheter for 1 hour. Participants will receive 4 LGG capsules and will repeat this process the following day twice for a total of four doses ("High" dose). Subjects will remain in the study for up to 29 months, with participation ending after one completed intervention (4 doses) and post-intervention assessments are complete. If urinary symptoms do not occur warranting instillation during the ensuing 29 months, participants will be asked to return any remaining kits (including LGG®). Participants will be instructed to complete the USQNB-IDC weekly until study completion.
- Primary Outcome Measures
Name Time Method Urinary Symptom Questionnaire for Neurogenic Bladder- Indwelling catheter (SA 2) 24-48 hours after intervention completion Will measure change in urinary symptoms for those that use an indwelling catheter. Higher score may mean worse outcomes. (local urine collection participants only)
Change in Urine Nitrite (SA 2) 24-48 hours after intervention completion urinalysis. (local urine collection participants only)
Change in Urine NGAL (SA 2) 24-48 hours after intervention completion Urine NGAL. (local urine collection participants only)
NINDS Medical History CDE: Baseline A brief medical history using body system categories
Change in Urine white blood cell count (SA 2) 24-48 hours after intervention completion urinalysis. (local urine collection participants only)
Change in Urine microbiome composition and function (SA 2) 24-48 hours after intervention completion Next generation sequencing for microbiome composition. (local urine collection participants only)
Change in Cultivable Bacteria (SA 2) 24-48 hours after intervention completion urine culture. (local urine collection participants only)
Medical History Form Baseline Medical history of participant
International SCI Lower Urinary Tract Function Basic Data Set Baseline A tool to describe urinary tract impairment, awareness of need to empty the bladder, main bladder emptying method, medications used for bladder management, surgeries, and change in urinary symptoms in the past year.
NINDS Prior and Concomitant Medications CDE Baseline Contains whether or not the participant is taking a medication during the study protocol, name of medication, reason for medication, medication dose, frequency, start and end dates, and free text
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
MedStar National Rehabilitation Hospital
🇺🇸Washington, District of Columbia, United States