The relationship between the shape of face and size of the airway in subjects with obstructive sleep apnoea syndrome
Completed
- Conditions
- Obstructive sleep apnoea-hypopnoea syndrome (OSAHS)Respiratory
- Registration Number
- ISRCTN18399406
- Lead Sponsor
- Bart’s & The London Dental Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- 132
Inclusion Criteria
1. 40 to 65 years old males
2. Clinically normal weight (BMI <25 Kg/m2) or obese (BMI >30Kg/m2)
3. Caucasian
4. Confirmed diagnosis of OSAHS in the study group and no clinically demonstrable OSAHS in control group
5. Dentate
6. The skin over the face and neck must be free of significant hair.
Exclusion Criteria
1. Edentulous subjects or the absence of 8 or more teeth in each dental arch
2. Facial neuromuscular disorders, craniofacial deformity or history of craniofacial surgery
3. Overweight subjects (BMI between 25 and 30 Kg/m2)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Facio-cervical morphology (phenotype)measured using image analysis software for stereophotogrammetry scan, lateral cephalometric radiograph, and cone-beam computed tomography (CBCT) at the second visit after baseline assessment.
- Secondary Outcome Measures
Name Time Method <br> 1. The correlation between the surface and skeletal facio-cervical morphology and upper airway dimensions using correlation analysis after the second visit<br> 2. Potentially identifying a facio-cervical marker for OSAHS subjects using multiple regression analysis after the second visit<br>