Acute Neuromuscular and Physiological Responses to Different Velocity Loss Thresholds During Power Training in Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Maximum Voluntary Contraction (MVC)
研究概览
简要总结
The goal of this clinical trial is to learn how older adults respond to power training when the level of fatigue during exercise is different. Power training means performing fast movements with moderate loads to improve strength, power and mobility.
The main questions the study aims to answer are:
- How does the level of fatigue during power training acutely affect strength, movement, and muscle function?
- How does it affect recovery, muscle soreness, and how hard the exercise feels?
Researchers will compare three power-training sessions with different fatigue levels to see which approach may be safest and most effective for older adults.
Participants will be healthy older adults aged 65 to 85 years. Each participant will complete three supervised exercise sessions on a leg press machine. The sessions will take place about one week apart.
During the study, participants will:
- Perform power training on a pneumatic leg press machine
- Complete strength and mobility tests before and after exercise
- Provide small blood samples to measure body responses to exercise
- Rate how hard the exercise feels
- Report muscle soreness for up to two days after exercise
The results may help researchers design safer and more effective power-training programs to improve strength, mobility, and recovery in older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 85 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants must:
- •Be 65 to 85 years old.
- •Be able to live independently and perform everyday activities without help.
- •Not have regularly done resistance or strength training in the past year.
- •Be able to understand study instructions and communicate in the study language.
- •Have a recent statement from their treating physician confirming that their heart and blood vessels are healthy enough to safely take part in this study.
排除标准
- •Participants will not be eligible if they have any of the following:
- •Unstable heart disease, neurological disease, acute infection, or fever.
- •Use of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, in the 5 days before the study.
- •Use of whey protein, casein, or amino acid supplements in the month before the study.
- •Acute or chronic injuries to the legs or lower body muscles.
- •Any injury or condition that prevents safe leg extension exercises.
- •Recent lower-limb joint replacement (less than 6 months ago).
- •Dependence on walking aids.
- •Current participation in another interventional trial.
研究组 & 干预措施
Low-Fatigue Power Training (10% velocity loss)
Participants perform a single supervised session of power training on a pneumatic leg press, consisting of 4 sets. During the exercise, movement speed is continuously monitored. In this arm, the exercise set will be stopped when movement speed decreases by 10% compared with the fastest repetition, which corresponds to a low level of fatigue (small amount of repetitions).
干预措施: Power Training at Different Fatigue Levels (Behavioral)
Moderate Fatigue Power Training (30% velocity loss)
Participants perform a single supervised session of power training on a pneumatic leg press, consisting of 4 sets. During the exercise, movement speed is continuously monitored. In this arm, the exercise set will be stopped when movement speed decreases by 30% compared with the fastest repetition, which corresponds to a moderate level of fatigue (more repetitions, performed closer to muscle failure).
干预措施: Power Training at Different Fatigue Levels (Behavioral)
Cluster-Set Power Training (10% Velocity Loss)
Participants perform a single supervised session of power training on a pneumatic leg press. In this arm, the exercise is organized into 4 cluster sets. A cluster set consists of small groups of repetitions separated by short rest periods within the set. Participants will perform clusters of 3-4 repetitions with 20 seconds of rest between clusters.
During the exercise, movement speed is continuously monitored. Each cluster will be performed within the range of 10% velocity loss compared with the fastest repetition, which corresponds to a low level of fatigue. Clusters will continue until the total number of repetitions matches the training volume (amount of total repetitions) reached in the 30% velocity loss condition.
This design allows participants to complete a similar total training volume as in the moderate fatigue condition, while maintaining lower fatigue, enabling researchers to separate the effects of exercise volume from the effects of fatigue.
干预措施: Power Training at Different Fatigue Levels (Behavioral)
结局指标
主要结局
Maximum Voluntary Contraction (MVC)
时间窗: Measurements will be taken before exercise (baseline), 5 minutes after each training session, and 24 hours after each session.
Maximum voluntary contraction (MVC) will be assessed to determine the maximum force-generating capacity of the leg extensors using an isokinetic dynamometer (Humac Norm). Simultaneously, muscle activity will be recorded using surface electromyography (EMG; Delsys EMG system). Primary outcome metric: Peak torque (Nm) obtained from three maximal isometric trials recorded on the dynamometer, combined with EMG amplitude (µV) to quantify muscle activation. Interpretation: Higher torque values indicate greater knee extensor strength. EMG amplitude reflects the level of muscle activation during maximal voluntary effort. Interpretation: Higher force values indicate greater leg muscle strength. EMG values indicate the level of muscle activation during the maximal effort.
次要结局
- Rate of Torque Development (RTD)(Measurements will be taken before exercise (baseline), 5 minutes after each training session, and 24 hours after each session.)
- Muscle Activity(Measurements will be taken before exercise (baseline), during exercise session (mean value across the full session), 5 minutes post exercise, and 24 hours post exercise (3 exercise sessions, 1 week apart))
- Strength Training Data: Mean Movement Velocity(During each exercise session (mean values across the full session) (3 Sessions ; ~1 week apart))
- Strength Training Data: Power(During each exercise session (mean value across the full session) (3 Sessions ; ~1 week apart))
- Strength Training Data: Total Number of Repetitions(During each exercise session (mean value across the full session) (3 Sessions ; ~1 week apart))
- Muscle Oxygenation(Baseline (pre-exercise), continuously during each exercise session, 5 minutes post-exercise, and 24 hours post-exercise (for each of the 3 sessions, 1 week apart))
- Blood Lactate(Measurements will be taken at baseline and immediately post exercise session (3 sessions, 1 week apart))
- Blood Gas(Measurements will be taken at baseline and immediately post exercise session (3 sessions, 1 week apart).)
- Creatine Kinase (CK)(Measurements will be taken at Baseline and 24 hours after each exercise session.)
- Functional Performance: Five-Repetition Sit-to-Stand Test(Measurements will be taken at Baseline, immediate post exercise and 24 hours after each exercise session.)
- Functional Performance: Counter Movement Jump(Measurements will be taken at Baseline, immediate post exercise and 24 hours after each exercise session.)
- Functional Performance: Stair Ascent test(Measurements will be taken at Baseline, immediate post exercise and 24 hours after each exercise session.)
- Functional Performance: 30-s Sit-to-Stand Test(Measurements will be taken at Baseline, immediate post exercise and 24 hours after each exercise session.)
- Perceived Exertion(Assessed after each exercise set during each exercise session (mean value across the full session) (3 Sessions ; ~1 week apart))
- Delayed Onset Muscle Soreness (DOMS)(Ratings will be collected at baseline, 24 hours after exercise, and 48 hours after exercise using a remote survey.)
研究者
Evelien Van Roie
Prof. Dr. Evelien Van Roie
Hasselt University