Evaluating the efficacy of Ivabradine in reducing the frequency of PAC , in patients with symptomatic frequent PACs

Phase 3

Recruiting

Conditions: Frequent premature atrial complex (PAC).
Atrial premature depolarization
I49.1

Registration Number: IRCT20230618058519N1

Lead Sponsor: Tehran heart center

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

Patient in ages between 18-75 years.
PAC frequency in ECG holter be between 5-10 % (average of 8%).
Patients who have the ability to understand and sign the letter of satisfaction.

Exclusion Criteria

Patient have the history of using Ivabradine during last 2 months.
Patients having cardiovascular disorders.
Patients having congenital long QT or QT>500 msec at the beginning of study.
using drugs with reducing heart rate effect, which have major interactions with Ivabradine.
Patients whom are pregnant or lactating or tending to become pregnant.
Patients suffering from advanced liver disease (class C of Child-Pugh score).
Patient having the history of using Ivabradine, whom has had discontinued Ivabradine because of adverse effects.
Patient having AF rhythm.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Frequency of PAC in 24 hours ECG holter. Timepoint: To understand the effect of Ivabradine on reducing the frequency of PAC, further holter will be done on 12th day of study for 24 hours. Method of measurement: ECG holter.

Secondary Outcome Measures

Name	Time	Method
Rate of reduction in PAC frequency in ECG holter. Timepoint: To understand the effect of Ivabradine on reducing the frequency of PAC, further holter will be done on 12th day of study for 24 hours. Method of measurement: 24 hours ECG holter.;Symptoms of patients with symptomatic frequent PACs. Timepoint: To understand the effect of Ivabradine on reducing the frequency of PAC, further holter will be done on 12th day of study for 24 hours. Method of measurement: 24 hours ECG holter.