The Influences of Caffeine on Heart Rate Variability of Preterm Infants

Completed

• Conditions: Autonomic Nervous System
• Interventions: Drug: Caffeine

• Registration Number: NCT01769118
• Lead Sponsor: Rambam Health Care Campus

Brief Summary

Caffeine has a stimulatory effect on the ANS. This has not yet been investigated in preterm infant who get caffeine before stopping ventilation. The investigators hypothesis is that this stimulatory effect may be characterized by HRV analysis methods.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01
• Study First Submitted: 2013-01-14
• Study First Submitted QC: 2013-01-15
• Study First Posted: 2013-01-16
• Primary Completion: 2014-01
• Study Completion: 2014-01
• Status Verified: 2015-05
• Last Update Submitted: 2015-05-06
• Last Update Posted: 2015-05-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• infants born before 34 weeks gestation

Exclusion Criteria

• sepsis
• congenital malformations

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Caffeine	Caffeine	caffeine will be given according to clinical judgment

Primary Outcome Measures

Name	Time	Method
Heart rate variability	1 hour	Heart rate, SD, SDNN, HF, LF, VLF, TP

Trial Locations

Locations (1)

RMC; 🇮🇱 Haifa, Israel