Effect of Incisal Loading during Orthodontic Treatment in Adults: RCT study

Completed

• Conditions: a history of generalized moderate/severe chronic periodontitis; Biomarkers, Periodontal disease(s)/periodontitis, Bone remodeling/regeneration, Cytokine(s), Orthodontic(s)

• Registration Number: TCTR20170625001
• Lead Sponsor: Graduate School, Prince of Songkla University

Brief Summary

abial and palatal bone thickness significantly increased (lower than twofold) from T1 to T3 in the experimental group at all three root levels (all P lower than 0.05). Bone thickness correlated negatively with RANKL/OPG ratio between T1 and T2 (P lower than 0.05). Tooth mobility, bone height, and density were not significantly different between T1 and T3.

Detailed Description

Not available

Study Timeline

• Study Completion: 2017-06-01
• Study Start: 2017-06-25
• Results First Posted: 2017-11-03
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 42

Inclusion Criteria

1) a history of generalized moderate/severe chronic periodontitis, as defined by Armitage (1999)
2) presently in the periodontal maintenance phase
3) upper incisors exhibiting a horizontal bone loss pattern with PTM and no incisal stop.

Exclusion Criteria

Patients with allergies, systemic diseases including uncontrolled osteoporosis, or long-term use of cigarettes or medications (e.g. anti-inflammatories, immunosuppressants, bisphosphonates, steroids) were excluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Alveolar bone changes initial (T0), ICS obtained(T1), 7th after ICS obtained (T3) mm changes from Cone beam computed tomography,RANKL/OPG initial (T0), ICS obtained(T1), 1mth after ICS obtained and 7th after ICS obtained (T3) ELISA kits

Secondary Outcome Measures

Name	Time	Method
Tooth mobility initial (T0), ICS obtained(T1), 1mth after ICS obtained and 7th after ICS obtained (T3) Miller grade