The Effects of Vasopressin on Attention Control: An Eye-tracking Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 89
- 试验地点
- 1
- 主要终点
- Effect of vasopressin administration on error rates of saccade/antisaccade for social (facial) versus non-social (shape) stimuli
研究概览
简要总结
The main aim of the present study is to investigate whether intranasal vasopressin (20IU) could influence attention control in a social-emotional saccade/antisaccade eye-tracking paradigm.
详细描述
A number of previous studies have reported vasopressin's effect on human social behavior and social cognition, although it remains unclear whether vasopressin could modulate attention allocation including stimulus-driven bottom-up control and goal-directed top-down control. In the current randomized, between-subject, placebo controlled study, 89 healthy male subjects will be recruited and receive either vasopressin (20 IU) or placebo control administered intranasally. 45 minutes after treatment subjects will be required to complete a social-emotional saccade /antisaccade eye-tracking paradigm. The paradigm uses social (happy, sad, angry, fear, and neutral faces) as well as non-social (oval shapes) stimuli to explore social- and emotion-specific effects of vasopressin.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy participants
- •Non smokers
排除标准
- •Previous or current medical, psychiatric, neurological disorder
- •Regular medication
- •Use of any psychoactive substances in the 24 hours before experiment
- •Contra-indications for vasopressin
- •Contra-indications for eye-tracking data acquisition
研究组 & 干预措施
Vasopressin
Vasopressin (20 IU) intranasally
干预措施: Vasopressin (Drug)
Placebo
Placebo intranasally
干预措施: Placebo (Drug)
结局指标
主要结局
Effect of vasopressin administration on error rates of saccade/antisaccade for social (facial) versus non-social (shape) stimuli
时间窗: 45 minutes - 100 minutes after treatment
Comparison between social-specific error rates of saccade/antisaccade between the vasopressin and placebo treatment conditions
Effect of vasopressin administration on saccade/antisaccade latencies towards social (facial) versus non-social (shape) stimuli
时间窗: 45 minutes - 100 minutes after treatment
Comparison between social-specific saccade/antisaccade latencies (in milliseconds) between the vasopressin and placebo treatment conditions
次要结局
- Emotion-specific effects of vasopressin administration on saccade/antisaccade error rates for the separate facial emotions(45 minutes - 100 minutes after treatment)
- Emotion-specific effects of vasopressin administration on saccade/antisaccade latencies towards the separate facial emotions(45 minutes - 100 minutes after treatment)
研究者
Keith Kendrick
Professor
University of Electronic Science and Technology of China