Multicenter Retrospective Evaluation Study of Pre-reconstruction Radiotherapy's Effect on One and Two Stages Prosthetic Breast Reconstruction and on Autologous Reconstruction
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Mammaplasty
- Sponsor
- Humanitas Clinical and Research Center
- Enrollment
- 2150
- Locations
- 1
- Primary Endpoint
- Reconstruction failure
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
For patients with breast cancer subject to a mastectomy, preserving the morphology of the breast with immediate reconstruction is a crucial aspect to preserve the quality of life.
There are several types of breast reconstruction: prosthetic in one or two stages and autologous reconstruction.
Adjuvant radiotherapy has shown an improvement of the overall survival and of the local control for patients with positive lymph nodes. As a consequence, plastic surgeons come into contact with more patients with a history of irradiation of their breasts than ever before.
However, there are few studies with a significant number that evaluate the effect of pre-reconstruction radiotherapy on the three types of reconstruction.
The aim of this study is to compare retrospectively these three types of reconstruction techniques to evaluate the impact of breast prior irradiation on the outcome of prosthetic reconstruction.
Investigators
Andrea Lisa
Principal Investigator
Humanitas Clinical and Research Center
Eligibility Criteria
Inclusion Criteria
- •Patients subjected to mastectomy and immediate reconstruction directly with prostheses, in two times and by autologue flaps (TRAM, Latissimus Dorsi Flap, DIEP and any other method)
Exclusion Criteria
- •Delayed prosthetic reconstruction
Outcomes
Primary Outcomes
Reconstruction failure
Time Frame: 2 years
Complication rate (as hematoma, seroma, prosthetic exposure, skin and fat necrosis) that resulted in explant (prosthetic, expander or flap)
Secondary Outcomes
- Reconstruction Complications(2 years)