Comparison of the Protective Effect of Desflurane and Propofol in Patients With Renal Transplantation

Phase 4

Completed

• Conditions: Healthy; End Stage Renal Disease
• Interventions: Drug: Desflurane; Drug: Propofol

• Registration Number: NCT01132157
• Lead Sponsor: Yonsei University

Brief Summary

Ischemia/reperfusion (IR) injury is the major cause of early renal dysfunction and acute renal failure of the transplanted kidney after renal transplantation. In 1986, Murry et al. described the phenomenon "ischemic preconditioning". Also, it was reported that a few non-ischemic stimuli could provide cellular tolerance against major ischemia through a mechanism similar to ischemic preconditioning. In an animal study, 1 minimal alveolar concentration of volatile anesthetics - a clinically relevant concentration - was reported to have a protective effect against ischemia/reperfusion injury, the effect being variable between types of anesthetics. Also, there were somm reports that intravenous anesthetics such as propofol could reduce IR injury by decreasing oxidative stress and apoptosis.

By reducing the ischemia/reperfusion injury of the grafted kidney, the morbidity and mortality related to renal transplantation can be reduced as well. The objective of this study is to find out whether, according to the type of anesthetics (Desflurane vs. Propofol), there is a difference in the protective effect against ischemia/reperfusion injury of the grafted kidney in patients receiving renal transplantation.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-03
• Study First Submitted: 2010-05-24
• Study First Submitted QC: 2010-05-26
• Study First Posted: 2010-05-27
• Primary Completion: 2012-01
• Study Completion: 2012-01
• Status Verified: 2014-03
• Last Update Submitted: 2014-03-04
• Last Update Posted: 2014-03-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 99

Inclusion Criteria

• healthy kidney donors and their recipients of renal transplantation.

Exclusion Criteria

• a donor that has any medical or surgical history,
• a recipient that is scheduled to have any other surgery with renal transplantation surgery.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Desflurane group	Desflurane	-
Propofol group	Propofol	-

Primary Outcome Measures

Name	Time	Method
estimated GFR(Glomerular Filtration Ratio)	1 hour after surgery	The primary outcome of our study is to find out whether, according to donors' anesthetics (desflurane or propofol), there is a difference in grafted kidney function postoperatively.
BUN(Blood Urea Nitrogen)	1 hour after surgery	The primary outcome of our study is to find out whether, according to donors' anesthetics (desflurane or propofol), there is a difference in grafted kidney function postoperatively.
Cr density	1 hour after surgery	The primary outcome of our study is to find out whether, according to donors' anesthetics (desflurane or propofol), there is a difference in grafted kidney function postoperatively.
urine output to check the the degree of protection for renal function	1 hour after surgery	The primary outcome of our study is to find out whether, according to donors' anesthetics (desflurane or propofol), there is a difference in grafted kidney function postoperatively.

Trial Locations

Locations (1)

Severance hospital, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of