A Cohort Study on the Clinical Characteristics and Prognosis of HIV/AIDS Patients Infected With SARS-CoV-2

Recruiting

• Conditions: PLWH; Clinical Features; Covid-19; Prognosis
• Interventions: Other: SARS-CoV-2

• Registration Number: NCT06172816
• Lead Sponsor: The Second Affiliated Hospital of Chongqing Medical University

Brief Summary

On February 11th, 2020, the International Classification of Viruses named the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as novel coronavirus (COVID-19, Covid-19 for short). At present, COVID-19 has become a global pandemic. However, the persistent replication of HIV in PLWH and the cellular immunodeficiency and persistent inflammation caused by it may have different effects on the susceptibility, severity and course of Covid-19. Several large cohort studies have found evidence of increased risk of hospitalization and death in patients with HIV and Covid-19 co-infection. Meanwhile, a meta-analysis of 22 studies shows that HIV infection is still an important risk factor for acquiring Covid-19 infection, and it is associated with a higher risk of death in COVID-19. In order to further clarify the clinical features and prognosis of HIV co-infection with Covid-19 and explore its immune mechanism, so we will carry out the study.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-01
• Study Start: 2023-01-01
• Study First Submitted: 2023-12-10
• Study First Submitted QC: 2023-12-13
• Last Update Submitted: 2023-12-13
• Study First Posted: 2023-12-15
• Last Update Posted: 2023-12-15
• Primary Completion: 2023-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Age 18-75 years old; Patients diagnosed with HIV in accordance with the Chinese AIDS Diagnosis and Treatment Guidelines.

Exclusion Criteria

• Hypertension, diabetes and other metabolic related diseases; Severe circulatory and respiratory diseases; Patients with immune-related diseases and immunosuppressants; Pregnant and lactating women.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
PLWH	SARS-CoV-2	the people living with HIV
HC	SARS-CoV-2	the people without disease

Primary Outcome Measures

Name	Time	Method
antibody titer	2022.11-2023.1	the SARS-CoV-2 specific antibody titers between healthy people and PLWH infected with Omicron
clinical features and prognosis	2022.11-2023.1	the clinical features and prognosis between healthy people and PLWH infected with Omicron

Trial Locations

Locations (1)

The second affiliated hospital of Chongqing medical university; 🇨🇳 Chongqing, Chongqing, China