Observational Study of Corneal Opacities in Adults
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- Identification of suitable subjects
Study Overview
Brief Summary
A prospective observational study on corneal opacities (scar and stromal dystrophy) in adults (n=150) will be conducted at OHSU. The Optovue anterior segment OCT will be used to perform 3-D corneal scans. These scans will be used to assess opacity depth and measure corneal thickness (pachymetry), corneal topography (anterior and posterior), and epithelial thickness maps. The ultrahigh-speed MIT OCT prototypes will also be used when they become available. A comprehensive eye examination, Placido-ring corneal topography, ultrasound pachymetry, and Scheimpflug camera imaging, will be performed for comparison.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 100 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Adult (18 & older) patients presenting in OHSU Casey Eye Clinic with corneal opacities (scar and stromal dystrophy)
Exclusion Criteria
- •Inability to give informed consent.
- •Inability to maintain stable fixation for OCT imaging.
- •Inability to commit to required visits to complete the study.
Outcomes
Primary Outcomes
Identification of suitable subjects
Time Frame: 2 years
The primary goal of this observational study is to identify suitable subjects for the clinical trials of OCT-guided transepithelial PTK.
Secondary Outcomes
- Validate OCT topography(2 years)
Investigators
David Huang
David Huang, MD, PhD, Professor of Ophthalmology, Oregon Health and Science University
Oregon Health and Science University