JPRN-UMIN000002395已完成1 期
Adoptive transfer of lymphocytes transduced with MAGE-A4-specific TCR gene for therapy-resistant esophageal cancer - Adoptive transfer of lymphocytes transduced with MAGE-A4-specific TCR gene
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 9
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 75years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1.Having following serious complications # Uncontrolled anigina pectoris, myocardial infarction, or heart failure # Uncontrolled diabetes mellitus or hytertention # Uncontrolled infection # X-ray-proven interstitial pneumonia or pulmonary fibrosis # Autoimmune disease # Bleeding tendency; PT less than 50%, APTT more than 60sec, serum fibrinogen less than 100mg/dL, FDP more than 20ug/mL Thrombosis tendency 2.History of serious hypersensitivity 3.Positive for HBs Ag, HCV Ab, HIV Ab, or HTLV-I Ab 4. Unctrolled pleural effusion, ascites, or pericardial effusion 5.Uncontrolled CNS metastasis 6.Systemic corticostoroid or immuno-suppressive therapy 7. Inappropriate for MAGE-A4 143-151 peptide administration, i.e. allergic to the peptide or adjuvant 8.Mental illness or drug dependency affecting informed consent 9.Pregnant, lactating, or possiblly pregnant women, or willing to be pregnant, or willing male partner, except having cryopreseved sperm 10. Lasting less than four weeks from the previous enrollment to clinical trials 11.Inappropriate for study entry judged by an attending physician.
研究者
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Adoptive transfer of lymphocytes transduced with MAGE-A4-specific TCR gene following lymphodepleting conditioning for therapy-resistant esophageal cancerTherapy-resistant esophageal cancerJPRN-UMIN000010729Department of Immuno-gene Therapy, Mie University Graduate School of Medicine12
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