Comparison of Permethrin and Ivermectin in Children Greater Than 6 Yrs Age for Treatment of Scabies

Phase 2

Not yet recruiting

• Conditions: Scabies
• Interventions: Drug: Permethrin Cream, 5%; Drug: Ivermectin 200 µg/kg

• Registration Number: NCT06896929
• Lead Sponsor: Children Hospital and Institute of Child Health, Lahore

Brief Summary

Scabies is highly contagious,pruritic infestation of skin.Various treatment modalities have been used but search for ideal scabicide is ongoing.we wnt to coduct this study to compare the outcome of permethrin verses ivermectin in children for treatment of scabies .This randomized clinical trial will be done in children hospital lahore for 12 months.Sample size of 90 cases;30 in each group will be included through non probability consecutive sampling.Then patient will be randomly divided into 3 groups.In group A patient will be given 5% permethrin topical application to whole body single application. In Group B ,patients will be given topical permethrin for twice application 24 hrs appart ,In group C patients will be given Tablet Ivermectin single dose 200microgram/kg.Then patients will be examined after 2 weeks and 4 weeks for no of lesions and pruritis and cure will be labeled.All this information will be recorded on performa .Data will be entered and analysed by using SPSS version 26.Three groups will be compared for cure by using chi-square test.P value less than and equal to 0.05 will be considered as significant.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-10
• Study First Submitted: 2025-03-20
• Study First Submitted QC: 2025-03-25
• Study First Posted: 2025-03-26
• Last Update Submitted: 2025-04-17
• Last Update Posted: 2025-04-20
• Study Start: 2025-05-01
• Primary Completion: 2026-04-01
• Study Completion: 2026-04-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Age 6-15
• Both genders
• Diagnosed with scabies (as per operational definition)

Exclusion Criteria

• Children with recurrent scabies on medical record
• Known allergy to ivermectin or permethrin.
• Widespread eczema or impetigo.
• Liver dysfunction or renal failure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group A	Permethrin Cream, 5%	Group A will be given Permethrin
Group B	Permethrin Cream, 5%	Group B will be given Permethrin 5% cream twice application
Group C	Ivermectin 200 µg/kg	Group C will be given Tab Ivermectin

Primary Outcome Measures

Name	Time	Method
Cure of scabies.	12 months	Cure will be labeled if greater han 50% reduction in no of lesions and pruritis observed after 4 weeks of treatment.

Trial Locations

Locations (1)

Children Hospital Lahore; 🇵🇰 Lahore, Punjab, Pakistan