Reduction of Septic Complications in High-Risk Compound Skull Fractures
- Conditions
- Nervous System Diseases
- Registration Number
- PACTR202402715350374
- Lead Sponsor
- one
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 116
All adults (age 18 and above) presenting with compound skull vault fractures who have:
1. Received primary wound care within 12 hours of injury.
2. Receive definitive surgery within 72 hours of injury.
3. Received a single dose of 2g Cefazolin intravenously within 12 hours of injury and have any one of the following risk factors for septic complications:
- air sinus involvement
- or clinical or radiological evidence of wound contamination
Children under the age of 18.
Gunshot injuries.
Septic complication at time of presentation.
Compound skull fractures with no high-risk features.
Patients suffering from base of skull fractures only.
Closed skull fractures.
Known antibiotic allergy.
Patients known with severe comorbidities such as end stage renal disease, heart failure, liver failure.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method A Reduction in the incidence of septic complications to 3 percent.
- Secondary Outcome Measures
Name Time Method eurological outcomes at 6 weeks post treatment follow will be assessed