The Glycaemic Effect of Isomaltulose Consumption in Healthy Participants

Not Applicable

Completed

• Conditions: Diabetes Mellitus
• Interventions: Other: Isomaltulose; Other: Sucrose

• Registration Number: NCT03020485
• Lead Sponsor: Clinical Nutrition Research Centre, Singapore

Brief Summary

The objective of this study is to determine the glycaemic effect of isomaltulose and sucrose in Chinese, Indian, Malay, and Caucasian individuals. The current study will provide important information on the potential health benefits of isomaltulose consumption in Asian population. It will also reveal how the three main ethnicities in Singapore respond to isomaltulose and whether the response differs from the Caucasians.

Detailed Description

The objective of the present study is to investigate the glycaemic effect of isomaltulose in Chinese, Indians, Malays and Caucasians. This will be a single intervention. Up to fifty participants, consisting of at least ten Chinese, ten Malays, ten Indians, and ten Caucasians completed data sets, aged between 21 and 40 years will be recruited from the general public in Singapore. Participants will be asked to attend two test sessions for this study. Participants will consume either a sucrose drink or an isomaltulose drink (each containing 50 g of available carbohydrate).

Study Timeline

• Study Start: 2014-12
• Primary Completion: 2016-09
• Study Completion: 2016-09
• Status Verified: 2017-01
• Study First Submitted: 2017-01-10
• Study First Submitted QC: 2017-01-11
• Last Update Submitted: 2017-01-11
• Study First Posted: 2017-01-13
• Last Update Posted: 2017-01-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

• Chinese, Indian, Malay or Caucasian ethnic origin

Exclusion Criteria

• People with major chronic disease such as heart disease, cancer or diabetes mellitus
• Individuals with food intolerances or allergies to isomaltulose or sucrose
• Individuals who are taking insulin or drugs known to affect glucose metabolism and body fat distribution
• People with a major medical or surgical event requiring hospitalization within the preceding 3 months
• Individuals with the presence of disease or drugs which influence digestion and absorption of nutrients
• Pregnant women

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Isomaltulose	Isomaltulose	50g of isomaltulose dissolved in 250ml of water
Sucrose	Sucrose	50g of sucrose dissolved in 250ml of water

Primary Outcome Measures

Name	Time	Method
Change in post prandial Blood glucose for 180 minutes period	180 minutes	Blood glucose obtained through finger pricks using Hemocue Glucose Analyser