Imbalances of Regional Pulmonary Ventilation in Patients With Post-acute-COVID-19

Active, not recruiting

• Conditions: COVID-19 Pneumonia; Electric Impedance; Post-acute COVID-19 Syndrome
• Interventions: Diagnostic Test: additional EIT Measurement

• Registration Number: NCT05238623
• Lead Sponsor: Jena University Hospital

Brief Summary

Investigation of the correlation of CT-morphological changes of the lung compared to regional ventilation distribution on electrical impedance tomography in patients with post-acute-Covid-19 symptoms.

Detailed Description

Prospective non-interventional, monocentric observational study on imbalances in regional lung ventilation compared to chest CT in post-acute-Covid-19. The aim is to verify the agreement between computerized tomography derived imaging variables and electrical impedance tomography in detecting lung ventilation imbalances. The primary study objective is to match CT morphological changes in regional ventilation in post-acute-COVID-19 patients and/or changes in lung function examination, with changes that can be visualized by electroimpedance tomography.

Study Timeline

• Study First Submitted: 2022-02-08
• Study First Submitted QC: 2022-02-11
• Study First Posted: 2022-02-14
• Study Start: 2022-03-01
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-13
• Last Update Posted: 2024-03-15
• Primary Completion: 2024-12-30
• Study Completion: 2025-03-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• all patients undergoing a Chest CT due to suspected post-acute-Covid-19-syndrome
• >18 years
• informed consent.

Exclusion Criteria

• trauma patients and patients with unstable spinal injuries or fractures
• patients with an BMI over 50
• patients with uncontrolled body movements
• Patients with a pacemaker

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Case cohort	additional EIT Measurement	Patients who receive standard CT and pulmonary function testing also receive electroimpedance tomography measurement

Primary Outcome Measures

Name	Time	Method
Correlation between tomography and electroimpedance tomography	until May 2022	The primary study objective is to match CT morphological changes in regional ventilation in post-COVID patients and/or changes in lung function examination with changes that can be visualized by electroimpedance tomography.

Secondary Outcome Measures

Name	Time	Method
Correlation between lung function testing and electroimpedance tomography	until May 2022

Trial Locations

Locations (1)

Klinik für Notfallmedizin; 🇩🇪 Jena, Thuringia, Germany