Clinical outcomes of an inflammatory bone disorder that may be associated with skin disorders.

Not Applicable

Completed

• Conditions: Synovitis Acne Pustulosis Hyperostosis and Osteitis syndrome; Inflammatory and Immune System - Autoimmune diseases; Musculoskeletal - Other muscular and skeletal disorders

• Registration Number: ACTRN12619000445178
• Lead Sponsor: Graeme Carroll

Brief Summary

This report illustrates the broad spectrum of disease presentations and severity in SAPHO. It also illustrates the disease progression over time and the responses to a variety of treatments or, in three cases, with no treatment. Mostly good or very good long-term treatment outcomes were observed in disease modifying agents (DMARDs) and biologic treatments. Suboptimal treatment may be associated with poorer clinical outcomes and greater skeletal damage. Just over half the participants studied were treated with biologic agents. Nine of 12 (75%) had a good primary response, extending for up to 14 years. It was concluded that TNFi therapy is mostly effective and moderately sustainable. The study has several limitations. The numbers of participants are small; most patients studies were Caucasian and therefore the results may not be generalizable to the wider population.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-12-02
• Study Start: 2019-03-18
• Last Update Posted: 15 July 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

Diagnosis of SAPHO as defined as multifocal osteitis with/without skin symptoms, sterile acute or chronic joint inflammation with either palmoplantar pustulosis or psoriasis, or acne or hidradenitis, with sterile osteitis with any one of these sets of criteria deemed sufficient for diagnosis.

Exclusion Criteria

Those people that did not meet the criteria required to be diagnosed with SAPHO (multifocal osteitis with/without skin symptoms, sterile acute or chronic joint inflammation with either palmoplantar pustulosis or psoriasis, or acne or hidradenitis, with sterile osteitis with any one of these sets of criteria).

Study & Design

• Study Type: Observational
• Study Design: Not specified