Study of antifungal drug susceptibility in fungal infections of the skin

Not yet recruiting

• Conditions: Superficial dermatophyte infections of the skin

• Registration Number: CTRI/2014/11/005219
• Lead Sponsor: IADVL

Brief Summary

An increasing trend of patients not responding to conventional oral as well as topical antifungal medications is seen recently all over the world due to indiscriminate use of antifungals.

It is of utmost importance to assess whether this clinical non-responsiveness of dermatophyte infections is due to  resistance to the drugs or due to various other factors such as compliance, dosage, drug interactions, other co-morbid conditions or altered pharmacokinetics. This will ultimately help to reduce the morbidity levels of what is believed to be an easily curable disease.

80 patients clinically diagnosed to be having superficial dermatophytosis will be included in the study after ruling out superadded bacterial infections

Specimen collection will be done from different sites ( skin, nails, hair) depending on site of involvement in the dermatology OPD. The specimen will be subjected to fungal culture followed by  species identification and drug susceptibilty testing against the following drugs: Terbinafine, griseofulvin , fluconazole, itraconazole, ketoconazole, clotrimazole and sertaconazole using broth microdilution method( CLSI M38-A)

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01-12
• Last Update Posted: 2014-11-21

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

All patients clinically diagnosed to be suffering from superficial dermatophytosis.

Exclusion Criteria

• Clinical evidence of superadded bacterial infection 2.
• Patients not consenting to provide a sample.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Identifying the causative agents responsible for dermatophyte infections in Mumbai, India	One Year
2. To determine the minimum inhibitory concentration values( MIC 50 & MIC 80 ) OF THE FOLLOWING DRUGS : Terbinafine, Griseofulvin, Fluconazole, Itraconazole, Ketoconazole, Clotrimazole and Sertaconazole against these dermatophytes	One Year

Secondary Outcome Measures

Name	Time	Method
To select the best antifungal drug for a patient of Dermatophytosis. thereby reducing the disease morbidity	1year

Trial Locations

Locations (1)

Department of Dermatology, K.J.Somaiya Medical College; 🇮🇳 (Suburban), MAHARASHTRA, India

Department of Dermatology, K.J.Somaiya Medical College

🇮🇳(Suburban), MAHARASHTRA, India

Dr Shital Poojary

Principal investigator

9820601511

spoojary2004@gmail.com