Analgesic Efficacy of Smoked Cannabis
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Score on a Visual Analog Scale (VAS) of pain severity
研究概览
简要总结
The purpose of this study is to determine whether or not inhaled marijuana displays any pain-relieving properties on experimentally-induced pain.
详细描述
It is important to evaluate the effects of the cannabinoids on facilitated pain as conditions of hyperalgesia more closely approximates the clinical situation. There are limited clinical studies on the effect of the cannabinoids on facilitated pain states. Noyes et al evaluated the analgesic effects of Delta-9-THC in 34 cancer patients with pain. They concluded that 20mg of oral Delta-9-THC was similar to 120mg of codeine (Noyes et al, 1975). Jain et al concluded that 1.5-3mg of intramuscular Levonantradol resulted in significant pain relief as compared to placebo in 56 patients with acute postoperative pain (Jain et al, 1981).
Comparison(s): Three different doses of smoked cannabis will be compared to placebo for the reduction of experimentally induced pain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-90
- •Male or Female
- •Subject smoked cannabis within the last six months
排除标准
- •Active opportunistic infections or opportunistic malignancies requiring acute treatment
- •Active substance abuse (alcohol or injection drug)
- •Pulmonary complications (e.g., tuberculosis, asthma)
- •Current use of cannabis (e.g., within 30 days of randomization)
- •Pregnancy as ascertained by a self-report and a mandatory commercial pregnancy test before any cannabis or placebo consumption condition
- •Personal or familial history of psychiatric disorder
结局指标
主要结局
Score on a Visual Analog Scale (VAS) of pain severity
McGill Pain Questionnaire (MPQ) Short Form
Neurosensory testing of: 1) warm and cold sensation, 2) warm and cold pain, 3) touch, and 4) mechanical pain. Testing administered using a Thermal Sensory Analyzer, von Frey hair filaments, and a pinch algometer, respectively.
次要结局
- Trail Making Test (TMT) as a measure of psychomotor speed.
- Paced Auditory Serial Attention Test (PASAT) as a measure of speed of information processing.