on-invasive markers for colorectal neoplasia A multi-marker approach in screening for colorectal cancer - Non-invasive markers for colorectal neoplasia

Academisch Ziekenhuis Maastricht0 个研究点目标入组 410 人开始时间: 待定最近更新: 2024年5月13日

适应症

试验速览

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•Subjects who will undergo a colonoscopy.
•1) average-risk population
•Employees (50-65 years of age) from companies participating in the ongoing workplace-based CRC screening project by colonoscopy have already been included.
•2) high-risk population
•Patients with a positive family history of CRC visiting the *outpatient clinic for hereditary colorectal cancer* or visiting the endoscopy unit of the MUMC+ for surveillance colonoscopy will be asked to participate into the study. This population will include patients with hereditary forms of CRC (Lynch syndrome or FAP) as well as patients fulfilling the criteria for familial CRC syndrome: i) ³ 1 first degree relative (FDR) with CRC diagnosed < 50 year or ii) ³ 2 FDR with CRC diagnosed between 50-70 year or iii) 1 FDR and 1 second degree relative with CRC diagnosed < 70 year.
•3) CRC patients
•Patients diagnosed with CRC, visiting the *emergency outpatient clinic* of the Division of Gastroenterology-Hepatology after the initial diagnosis of CRC and before subsequent therapeutic interventions are started, will be included.
•Additionally, a subset of patients diagnosed with either oesophageal, gastric or pancreatic cancer will be included at our *emergency outpatient clinic* of the Division of Gastroenterology-Hepatology after initial diagnosis and before subsequent therapeutic interventions are started. We will include 20 patients for each group of non-colorectal gastrointestinal malignancy.

•Individuals will be excluded if:
•-younger than 18 years old
•-diagnosed with inflammatory bowel disease (Crohn*s disease or ulcerative colitis)
•-diagnosed with major co-morbidity which may interfere with the outcome of the study (e.g. severe cardiovascular or pulmonary disease, other malignancies)

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