Establishing a Non-invasive Diagnostic Biomarker Test for Early Diagnosis of Lung Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- DNA Methylation at early stages of lung cancer
研究概览
简要总结
Data on SHOX2 and PTGER4 DNA Methylation suggest possible use as a biomarker for early lung cancer diagnosis.
In this study a control group consisting of COPD patients with a CT-scan of the chest no older than 6 weeks and a control group of patients with a nodule and ruled out diagnosis of lung cancer will be included.
SHOX2 and PTGER4 will be analyzed via PCR.
详细描述
Data on SHOX2 and PTGER4 DNA Methylation suggest possible use as a biomarker for early lung cancer diagnosis.
In this study a control group consisting of COPD patients with a CT-scan of the chest no older than 6 weeks and a control group of patients with a nodule and ruled out diagnosis of lung cancer will be included.
A total of 150 patients will be enrolled in this study. SHOX2 and PTGER4 will be analyzed via PCR of blood plasma samples.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •suspicious finding for lung cancer on CT-scan
排除标准
- •history significant for former malignant diseases
结局指标
主要结局
DNA Methylation at early stages of lung cancer
时间窗: 1 year
次要结局
未报告次要终点
研究者
Kaid Darwiche
Priv.-Doz. Dr. med. Kaid Darwiche, head of department of interventional pneumology
University Hospital, Essen