Effect of Magnesium Sulphate on depth of Anaesthesia, awareness incidence and pain relief after abdominal surgery-a parallel group, single blind,prospective randomised controlled trial.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- bispectral index
研究概览
简要总结
A total of 100 patients of ASA I and II,18-60 years of age of either sex undergoing abdominal surgery under general anaesthesia will be randomly allocated into two equal groups.BIS monitor will be attached to assess depth of anaesthesia, and data will be collected before induction(BIS 0),at five minutes (BIS 5),then every 15 minutes.Group S will receive 20ml 0.9% Normal saline(NS) over 15-20 seconds and 500ml 0.9% NS at 15ml/kg/hour. Group SM will receive 20ml 0.9% NS with Magnesium sulphate 40mg/kg over 15-20 seconds and 500ml 0.9% NS with Magnesium sulphate at 15mg/kg/hour.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Undergoing Abdominal surgery.
排除标准
- •Patient with hypermagnesaemia -Patient with any heart block -Patient with hypertension -Patient with diabetes mellitus -Patient with pre-term pregnancy, multiple pregnancies -Patient’s refusal.
结局指标
主要结局
bispectral index
时间窗: Baseline,5 minutes then every 15 minutes
次要结局
- 1)To access the effect of magnesium sulphate on pain relief as well as incidence of awareness after abdominal surgery. 2)To evaluate the total analgesic consumption during first post-operative day. 3)To observe the time for first rescue analgesia. 4)To study haemodynamic variables( Pulse rate,Mean arterial pressure) 5)To study drug side effects if any.(Baseline,5 minutes then every 15 minutes,post operative day 1)
研究者
RAJ BHUSAN PRASAD
Institute Of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital