Study of Segmental Renal Artery Clamping During Laparoscopic Partial Nephrectomy

Not Applicable

• Conditions: Kidney Neoplasms; Renal Cell Carcinoma
• Interventions: Procedure: Segmental artery clamping; Procedure: Main renal artery clamping

• Registration Number: NCT01892059
• Lead Sponsor: The First Affiliated Hospital with Nanjing Medical University

Brief Summary

The purpose of this study is to compare the efficacy and safety of the segmental artery clamping and main renal artery clamping during laparoscopic partial nephrectomy

Detailed Description

Renal tumor patients,for whom laparoscopic partial nephrectomy is suitable, will be randomly divided into two groups,segmental artery clamping group and main artery clamping group. All procedures were performed by the same laparoscopic surgeon. Blood loss, operation time, warm ischemia time, complications and affected renal function before and after operation will be recorded and compared. The safety and efficiency of laparoscopic partial nephrectomy with segmental renal artery clamping will be evaluated in comparison with the conventional main renal artery clamping technique.

Study Timeline

• Study Start: 2013-05
• Status Verified: 2013-06
• Study First Submitted: 2013-06-30
• Study First Submitted QC: 2013-07-02
• Last Update Submitted: 2013-07-02
• Study First Posted: 2013-07-03
• Last Update Posted: 2013-07-03
• Primary Completion: 2015-05
• Study Completion: 2016-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• 20<age<70yr
• Stage T1a
• Patients volunteered for this study and provided written informed consent

Exclusion Criteria

• Bilateral renal tumor
• tumor of solitary kidney
• glomerulonephritis
• renal insufficiency
• GFR of invalid kidney less than 30ml/min
• presence of suspect metastasis
• serious systematic disease: severe coagulation disorders
• important organ insufficiency and severe psychological disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Segmental artery clamping	Segmental artery clamping	Patients with Renal tumor are randomized into this group,they will received laparoscopic partial nephrectomy. During operation, the technique of segmental renal artery clamping will performed.
Main renal artery clamping	Main renal artery clamping	Patients with renal tumor are randomized into this group,they will received laparoscopic partial nephrectomy. During operation, the technique of traditional main renal artery clamping will be performed.

Primary Outcome Measures

Name	Time	Method
Glomerular Filtration Rate	3 months postoperative

Secondary Outcome Measures

Name	Time	Method
warm ischemia time	during surgery

Trial Locations

Locations (1)

Department of Urology, First Affiliated Hospital of Nanjing Medical University; 🇨🇳 Nanjing, Jiangsu, China