Comparison of Propofol Based Anesthesia and Postoperative Sedation (PA) Versus Volatile Anesthetics Based Anesthesia and Postoperative Sedation (VA) in Cardiac Surgical Patients
Overview
- Phase
- N/A
- Intervention
- Propofol
- Conditions
- Cardiac Surgery
- Sponsor
- University Health Network, Toronto
- Enrollment
- 146
- Locations
- 1
- Primary Endpoint
- The composite primary end point of the trial will be the development of enzymatic signs of myocardial injury or MI, postoperative low output syndrome, or both. Enzymatic MI will be determined after obtaining serial measurements of troponin.
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
All patients undergoing cardiac surgery require intraoperative anesthesia and short-term postoperative sedation with anesthetic agents after the procedure when patient is in the intensive care unit (ICU). The clinical data obtained so far are concentrating on intraoperative use volatile agents (preconditioning) resulting in better postoperative cardiac function and less release of biochemical markers of myocardial damage. There are no studies investigating whether postoperative use of volatile agents (post conditioning) in cardiac surgical population is improving outcomes. The aim of the present study is to compare total intravenous anesthesia and postoperative sedation versus total volatile anesthesia and postoperative sedation in cardiac surgical population.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
PA-Intravenous Sedation
Propofol based total intravenous anesthesia and postoperative sedation
Intervention: Propofol
Volatile sedation
Total inhalational anesthesia and postoperative sedation with the AnaConda device
Intervention: Isoflurane/sevoflurane
Outcomes
Primary Outcomes
The composite primary end point of the trial will be the development of enzymatic signs of myocardial injury or MI, postoperative low output syndrome, or both. Enzymatic MI will be determined after obtaining serial measurements of troponin.
Time Frame: Measurements of troponin levels will be after induction of anesthesia (baseline) and at 0, 2, 4, 8, and 24 h after arrival into the ICU.
Secondary Outcomes
- Quality of sedation(Post ICU arrival POD 0 to discharge (2hours to on average 5-7 days until discharge))
- Incidence of delirium(Post ICU arrival POD 0 to discharge (2hours to on average 5-7 days until discharge))
- Time to readiness for extubation, time to extubation(Post ICU arrival POD 0 to discharge (2hours to on average 5-7 days until discharge))
- Length of stay within ICU, readiness for discharge from the unit(Post ICU arrival POD 0 to discharge (2hours to on average 5-7 days until discharge))