Study of Cortical Excitability in Healthy Subjects With Transcranial Magnetic Stimulation (TMS) and a Neuronavigation Device
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 75
- 试验地点
- 2
- 主要终点
- Amplitudes of Motor evoked Potentials (µV) for ICI and ICF.
研究概览
简要总结
This study has two main goals :
- to investigate the impact of aging on cortical excitability (CE)
- to investigate the impact of "state dependency" on CE, using a cognitive task and an emotional one.
A Neuronavigation system of transcranial magnetic stimulation is used, and electromyographic response are recorded.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •male or female
- •age 18-75
- •signed informed consent
- •normal physical examination
排除标准
- •less 18 or more 75 years of age
- •contra indication to TMS: epilepsia or seizures, metallic head devices, cardiac pacemaker, pregnancy, jet lag or severe insomnia the night before
- •severe physical disease
- •treatment with psychotropic drugs
- •overt psychiatric disease
- •alcohol consumption before the examination
结局指标
主要结局
Amplitudes of Motor evoked Potentials (µV) for ICI and ICF.
时间窗: Participants will be followed for an expected average of one month
Motor Evoked Potential (MEP) from the first dorsal interosseous are register during the stimulations. Intracortical Inhibition (ICI) and Facilitation (ICF) are a paired-pulse TMS measure of cortical excitability. A short Interval interstimuli (2ms) leads to a cortical inhibition, which reflects the GABAergic neurotransmission; whereas a longer interval interstimuli leads to a cortical facilitation, which reflects glutamatergic neurotransmission.
Durations of Cortical Silent Period (ms)
时间窗: Participants will be followed for an expected average of one month
Cortical Silent Period (CSP) is a single-pulse TMS measure of cortical inhibition, stimulations are applied while subjects are exerting a muscular contraction of the thum-index pinch and lead to a muscular cancellation. Duration of this silence is measured.
次要结局
未报告次要终点