Effect of the choice of postoperative maintenance infusion on patient prognosis:an open-label, randomized controlled trial.
Not Applicable
Recruiting
- Conditions
- postoperative critically ill patients
- Registration Number
- JPRN-UMIN000031160
- Lead Sponsor
- Kobe university graduate school of medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 225
Inclusion Criteria
Not provided
Exclusion Criteria
1) Patients with preoperative eGFR <= 50 ml / min. 2) Patients with preoperative total bilirubin value >= 2 mg / dL. 3) Patients with a history of heart failure 4) Pregnant women and patients who may be pregnant or breast-feeding patients. 5) Patients who are judged to be inappropriate.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of hyponatremia (serum Na concentration less than 136 mmol/L) 3 days after surgery.
- Secondary Outcome Measures
Name Time Method 1) Changes in serum vasopressin concentration, cortisol concentration, serum BNP concentration and urinary electrolyte concentration immediately after surgery and on the 1st to 3rd postoperative days. 2) Changes in serum S100 beta concentration and serum neuron-specific enolase concentration immediately after surgery and on the 1st to 3rd postoperative days. 3) Incidence of postoperative delirium during stay in the ICU. 4) Incidence and severity of postoperative organ injury during stay in the ICU 5) ICU-free survival days for 28 days after surgery.