NCT04770922已完成不适用
Pharmacogenomic Analysis of 6-mercaptopurine in Pediatric Acute Lymphoblastic Leukemia
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Novel genetic variants impact on 6-mercaptopurine adverse drug reactions
研究概览
简要总结
This is a retrospective biobank study evaluating the impact of novel genetic variants in a population of 6-mercaptopurine treated pediatric acute lymphoblastic leukemia patients.
详细描述
The study objective is to clinically validate that the presence of recently discovered novel genetic variation adversely affects a population of 6-mercaptopurine treated pediatric acute lymphoblastic leukemia patients using biobank samples.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pediatric acute lymphoblastic leukemia (ALL) subjects
- •Received 6-mercaptopurine
- •Available biobank (bone marrow or blood) sample(s) from which deoxyribonucleic acid (DNA) can be extracted
- •White blood cell (WBC) levels
排除标准
- •Pediatric ALL subjects who did NOT receive 6-mercaptopurine
- •No biobank sample
- •No WBC level
结局指标
主要结局
Novel genetic variants impact on 6-mercaptopurine adverse drug reactions
时间窗: 1 year
Objective is to clinically validate the presence of novel genetic variants and its impact on adverse drug reactions in a population of pediatric ALL patients treated with 6-MP
次要结局
- Evaluating relationship of genetic variants to ancestry(1 year)
研究者
研究点 (1)
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