A Single Site Prospective Descriptive Study on the Effect of Brachytherapy Monotherapy for Prostate Cancer on Male Fertility
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- To define effect of prostate brachytherapy on male fertility.
研究概览
简要总结
Although brachytherapy toxicity data on erectile dysfunction, urethral dysfunction and bladder and bowel impact has been collected for a number of years, there is limited information on its effect on male fertility. This study aims to investigate the effect of brachytherapy on fertility
详细描述
Brachytherapy is a commonly employed technique in the treatment of all prostate cancer risk groups. It delivers a high radiation localised to the prostate gland. The effects of this on fertility have not been systematically studied. An increasing number of younger men for whom fertility is an issue are being diagnosed with prostate cancer and may be offered brachytherapy amongst their treatment choices. This study therefore addresses this issue with a systematic evaluation of sperm count and quality before and after both high dose rate and low dose rate brachytherapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •18 years or older
- •Receiving brachytherapy monotherapy; High or Low dose rate
- •Ability to ejaculate
- •Able to provide written informed consent
排除标准
- •History of infertility or vasectomy
- •Previous chemotherapy or pelvic radiotherapy
- •Prior use of androgen deprivation therapy
- •5 alpha-reductase inhibitors within the last 4 months
- •Alpha blockers within 7 days of semen collection
结局指标
主要结局
To define effect of prostate brachytherapy on male fertility.
时间窗: 12 months
measure by sequential sperm counts
次要结局
未报告次要终点