Evaluation of technology and performance of novel free radical imaging system (DNP-MRI)
Not Applicable
- Conditions
- healthy volunteers
- Registration Number
- JPRN-UMIN000020724
- Lead Sponsor
- Kyushu University, Innovation Center for Medical Redox Navigation
- Brief Summary
We developed a novel field-cycling DNP-MRI system for a preclinical study. The image quality was examined using various pulse sequences and ESR irradiation using nitroxyl radical as the phantom, and the optimum conditions were established. Using the system, we performed a preclinical study involving free radical imaging by placing the free radicals under the palm of a human hand.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Male
- Target Recruitment
- 3
Inclusion Criteria
Not provided
Exclusion Criteria
1. People who have electrically, magnetically or mechanically activated implants (such as cardiac pacemakers). 2. People who have serious conditions such as cardiac decompensation. 3. Any other people who are regarded as unsuitable for this study by the principal investigator.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences between images obtained by field-cycled DNP-MRI achieved by magnet rotation and those by field-cycled MRI, and signal intensities of free radicals deduced from them. Temperature increase of surface coil sites and skin surface during image acquisition.
- Secondary Outcome Measures
Name Time Method Resolution of images obtained by static MRI, resolution of images obtained by field-cycled MRI achieved by magnet rotation.